Novel T cell driven approach leads to the identification of immunoprevalent antigens

Valeria A. Judkowski; Radleigh G. Santos; Alcinette Bunying; Marc A. Giulianotti; Jon R. Appel; Clemencia Pinilla

doi:10.1016/j.provac.2012.04.004

Novel T cell driven approach leads to the identification of immunoprevalent antigens

Valeria A. Judkowski
, Radleigh G. Santos
, Alcinette Bunying
, Marc A. Giulianotti
, Jon R. Appel
, Clemencia Pinilla

Department of Mathematics

Research output: Contribution to journal › Article › peer-review

Abstract

The prevention and treatment of infectious diseases is highly dependent on the availability of reliable diagnostic tests and protective or therapeutic vaccines. There also exists an urgent need to develop reliable biomarkers to monitor treatment success and to predict disease progression from asymptomatic to symptomatic disease in several infectious diseases. The elucidation of the disease-relevant antigens that elicit the protective immune responses is critical and required for the development of diagnostics and treatments. Here we present a novel " T cell driven approach" that permits the direct identification of pathogen epitopes and protein antigens capable of triggering specific T cell responses upon immunization in humans. © 2012.

Original language	American English
Pages (from-to)	14-20
Journal	Procedia in Vaccinology
Volume	6
DOIs	https://doi.org/10.1016/j.provac.2012.04.004
State	Published - May 7 2012

Access to Document

10.1016/j.provac.2012.04.004License: Unspecified

http://nsuworks.nova.edu/math_facarticles/337

Cite this

@article{71c36e010bdc4f8e999683166fa0ab9b,

title = "Novel T cell driven approach leads to the identification of immunoprevalent antigens",

abstract = "The prevention and treatment of infectious diseases is highly dependent on the availability of reliable diagnostic tests and protective or therapeutic vaccines. There also exists an urgent need to develop reliable biomarkers to monitor treatment success and to predict disease progression from asymptomatic to symptomatic disease in several infectious diseases. The elucidation of the disease-relevant antigens that elicit the protective immune responses is critical and required for the development of diagnostics and treatments. Here we present a novel {"} T cell driven approach{"} that permits the direct identification of pathogen epitopes and protein antigens capable of triggering specific T cell responses upon immunization in humans. {\textcopyright} 2012.",

author = "Judkowski, \{Valeria A.\} and Santos, \{Radleigh G.\} and Alcinette Bunying and Giulianotti, \{Marc A.\} and Appel, \{Jon R.\} and Clemencia Pinilla",

year = "2012",

month = may,

day = "7",

doi = "10.1016/j.provac.2012.04.004",

language = "American English",

volume = "6",

pages = "14--20",

journal = "Procedia in Vaccinology",

issn = "1877-282X",

}

TY - JOUR

T1 - Novel T cell driven approach leads to the identification of immunoprevalent antigens

AU - Judkowski, Valeria A.

AU - Santos, Radleigh G.

AU - Bunying, Alcinette

AU - Giulianotti, Marc A.

AU - Appel, Jon R.

AU - Pinilla, Clemencia

PY - 2012/5/7

Y1 - 2012/5/7

N2 - The prevention and treatment of infectious diseases is highly dependent on the availability of reliable diagnostic tests and protective or therapeutic vaccines. There also exists an urgent need to develop reliable biomarkers to monitor treatment success and to predict disease progression from asymptomatic to symptomatic disease in several infectious diseases. The elucidation of the disease-relevant antigens that elicit the protective immune responses is critical and required for the development of diagnostics and treatments. Here we present a novel " T cell driven approach" that permits the direct identification of pathogen epitopes and protein antigens capable of triggering specific T cell responses upon immunization in humans. © 2012.

AB - The prevention and treatment of infectious diseases is highly dependent on the availability of reliable diagnostic tests and protective or therapeutic vaccines. There also exists an urgent need to develop reliable biomarkers to monitor treatment success and to predict disease progression from asymptomatic to symptomatic disease in several infectious diseases. The elucidation of the disease-relevant antigens that elicit the protective immune responses is critical and required for the development of diagnostics and treatments. Here we present a novel " T cell driven approach" that permits the direct identification of pathogen epitopes and protein antigens capable of triggering specific T cell responses upon immunization in humans. © 2012.

U2 - 10.1016/j.provac.2012.04.004

DO - 10.1016/j.provac.2012.04.004

M3 - Article

SN - 1877-282X

VL - 6

SP - 14

EP - 20

JO - Procedia in Vaccinology

JF - Procedia in Vaccinology

ER -

Novel T cell driven approach leads to the identification of immunoprevalent antigens

Abstract

Access to Document

Fingerprint

Cite this