Obesity-related kidney disease

Samuel K Snyder; G A Turner; A Turner

doi:10.1016/j.pop.2014.08.008

Obesity-related kidney disease

Samuel K Snyder
, G A Turner
, A Turner

Research output: Contribution to journal › Article › peer-review

Abstract

The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.

Original language	American English
Journal	Primary Care: Clinics in Office Practice
Volume	41
DOIs	https://doi.org/10.1016/j.pop.2014.08.008
State	Published - Dec 1 2014

Keywords

Adipocytes
Age Factors
Blood Glucose
Chronic
Cytokines
Dyslipidemias
Genetic Predisposition to Disease
Health Behavior
Humans
Hypertension
Inflammation
Insulin Resistance
Life Style
Obesity
Prevalence
Renal Insufficiency
Renin-Angiotensin System
Risk Factors
Sex Factors
Sympathetic Nervous System
United States

Disciplines

Medical Specialties
Medicine and Health Sciences
Osteopathic Medicine and Osteopathy

Access to Document

10.1016/j.pop.2014.08.008License: Unspecified

Cite this

@article{9230b0559fd64b1a848007d781a1e27f,

title = "Obesity-related kidney disease",

abstract = " The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.",

keywords = "Adipocytes, Age Factors, Blood Glucose, Chronic, Cytokines, Dyslipidemias, Genetic Predisposition to Disease, Health Behavior, Humans, Hypertension, Inflammation, Insulin Resistance, Life Style, Obesity, Prevalence, Renal Insufficiency, Renin-Angiotensin System, Risk Factors, Sex Factors, Sympathetic Nervous System, United States",

author = "Snyder, \{Samuel K\} and Turner, \{G A\} and A Turner",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.pop.2014.08.008",

language = "American English",

volume = "41",

journal = "Primary Care: Clinics in Office Practice",

issn = "0095-4543",

}

TY - JOUR

T1 - Obesity-related kidney disease

AU - Snyder, Samuel K

AU - Turner, G A

AU - Turner, A

PY - 2014/12/1

Y1 - 2014/12/1

N2 - The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.

AB - The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.

KW - Adipocytes

KW - Age Factors

KW - Blood Glucose

KW - Chronic

KW - Cytokines

KW - Dyslipidemias

KW - Genetic Predisposition to Disease

KW - Health Behavior

KW - Humans

KW - Hypertension

KW - Inflammation

KW - Insulin Resistance

KW - Life Style

KW - Obesity

KW - Prevalence

KW - Renal Insufficiency

KW - Renin-Angiotensin System

KW - Risk Factors

KW - Sex Factors

KW - Sympathetic Nervous System

KW - United States

UR - https://nsuworks.nova.edu/hpd_com_faculty_articles/1112

U2 - 10.1016/j.pop.2014.08.008

DO - 10.1016/j.pop.2014.08.008

M3 - Article

SN - 0095-4543

VL - 41

JO - Primary Care: Clinics in Office Practice

JF - Primary Care: Clinics in Office Practice

ER -

Obesity-related kidney disease

Abstract

Keywords

Disciplines

Access to Document

Other files and links

Fingerprint

Cite this