Abstract
Choline displaced [3H]QNB binding from rat brain muscarinic receptors competitively, (Ki = 460 μM) but it was only 1/1000th as potent as ACh. Deanol was an extremely weak displacer of [3H]QNB binding while hemicholinium-3 was 50 times more potent than choline. Although brain levels of choline are well below its Ki value for muscarinic receptors, choline may directly interact with rat brain muscarinic receptors in some circumstances.
| Original language | English |
|---|---|
| Pages (from-to) | 197-201 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 58 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 15 1979 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Pharmacology
Keywords
- Brain muscarinic receptors
- Choline
- Dimethylaminoethanol
- Hemicholinium-3
- [H]Quinuclidinyl benzilate
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