Palifermin

Vladimir Beljanski

doi:10.1016/B978-008055232-3.64487-3

Palifermin

Vladimir Beljanski

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Palifermin is a human recombinant keratinocyte growth factor (KGF) produced in Escherichia coli. When patients with blood cancers undergo high dose chemotherapy and radiation to undergo bone marrow transplant, they usually get severe oral mucositis. Palifermin binds to epithelial cell-surface receptors and stimulates epithelial cell proliferation, differentiation, and up-regulation of cytoprotective mechanisms. It reduces the incidence and duration of severe oral mucitis by protecting those cells and stimulating the growth of new epithelial cells to build up the mucosal barrier... © 2009

Original language	English
Title of host publication	xPharm
Subtitle of host publication	The Comprehensive Pharmacology Reference
Editors	S.J. Enna, David B. Bylund
Publisher	Elsevier Inc.
Pages	1-4
Number of pages	4
ISBN (Print)	9780080552323
DOIs	https://doi.org/10.1016/B978-008055232-3.64487-3
State	Published - 2009
Externally published	Yes

ASJC Scopus Subject Areas

General Pharmacology, Toxicology and Pharmaceutics

Disciplines

Medicine and Health Sciences

Access to Document

10.1016/B978-008055232-3.64487-3

Cite this

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title = "Palifermin",

abstract = "Palifermin is a human recombinant keratinocyte growth factor (KGF) produced in Escherichia coli. When patients with blood cancers undergo high dose chemotherapy and radiation to undergo bone marrow transplant, they usually get severe oral mucositis. Palifermin binds to epithelial cell-surface receptors and stimulates epithelial cell proliferation, differentiation, and up-regulation of cytoprotective mechanisms. It reduces the incidence and duration of severe oral mucitis by protecting those cells and stimulating the growth of new epithelial cells to build up the mucosal barrier... {\textcopyright} 2009",

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N2 - Palifermin is a human recombinant keratinocyte growth factor (KGF) produced in Escherichia coli. When patients with blood cancers undergo high dose chemotherapy and radiation to undergo bone marrow transplant, they usually get severe oral mucositis. Palifermin binds to epithelial cell-surface receptors and stimulates epithelial cell proliferation, differentiation, and up-regulation of cytoprotective mechanisms. It reduces the incidence and duration of severe oral mucitis by protecting those cells and stimulating the growth of new epithelial cells to build up the mucosal barrier... © 2009

AB - Palifermin is a human recombinant keratinocyte growth factor (KGF) produced in Escherichia coli. When patients with blood cancers undergo high dose chemotherapy and radiation to undergo bone marrow transplant, they usually get severe oral mucositis. Palifermin binds to epithelial cell-surface receptors and stimulates epithelial cell proliferation, differentiation, and up-regulation of cytoprotective mechanisms. It reduces the incidence and duration of severe oral mucitis by protecting those cells and stimulating the growth of new epithelial cells to build up the mucosal barrier... © 2009

UR - https://www.scopus.com/pages/publications/84884058818

UR - https://www.scopus.com/pages/publications/84884058818#tab=citedBy

U2 - 10.1016/B978-008055232-3.64487-3

DO - 10.1016/B978-008055232-3.64487-3

M3 - Chapter

AN - SCOPUS:84884058818

SN - 9780080552323

SP - 1

EP - 4

BT - xPharm

A2 - Enna, S.J.

A2 - Bylund, David B.

PB - Elsevier Inc.

ER -

Palifermin

Abstract

ASJC Scopus Subject Areas

Disciplines

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