Phagosomal TLR signaling upon Borrelia burgdorferi infection

Jorge L. Cervantes; Kelly L. Hawley; Sarah J. Benjamin; Bennett Weinerman; Stephanie M. Luu; Juan C. Salazar

doi:10.3389/fcimb.2014.00055

Phagosomal TLR signaling upon Borrelia burgdorferi infection

Jorge L. Cervantes
, Kelly L. Hawley
, Sarah J. Benjamin
, Bennett Weinerman
, Stephanie M. Luu
, Juan C. Salazar

Research output: Contribution to journal › Review article › peer-review

Abstract

Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete.

Original language	English
Article number	55
Journal	Frontiers in Cellular and Infection Microbiology
Volume	4
Issue number	MAY
DOIs	https://doi.org/10.3389/fcimb.2014.00055
State	Published - 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Cervantes, Hawley, Benjamin, Weinerman, Luu and Salazar.

ASJC Scopus Subject Areas

Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

Keywords

Borrelia burgdorferi
Innate immunity
Lyme disease
Phagosomal signaling
Toll-like receptors

Access to Document

10.3389/fcimb.2014.00055

Cite this

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title = "Phagosomal TLR signaling upon Borrelia burgdorferi infection",

abstract = "Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete.",

keywords = "Borrelia burgdorferi, Innate immunity, Lyme disease, Phagosomal signaling, Toll-like receptors",

author = "Cervantes, \{Jorge L.\} and Hawley, \{Kelly L.\} and Benjamin, \{Sarah J.\} and Bennett Weinerman and Luu, \{Stephanie M.\} and Salazar, \{Juan C.\}",

note = "Publisher Copyright: {\textcopyright} 2014 Cervantes, Hawley, Benjamin, Weinerman, Luu and Salazar.",

year = "2014",

doi = "10.3389/fcimb.2014.00055",

language = "English",

volume = "4",

journal = "Frontiers in Cellular and Infection Microbiology",

issn = "2235-2988",

number = "MAY",

}

TY - JOUR

T1 - Phagosomal TLR signaling upon Borrelia burgdorferi infection

AU - Cervantes, Jorge L.

AU - Hawley, Kelly L.

AU - Benjamin, Sarah J.

AU - Weinerman, Bennett

AU - Luu, Stephanie M.

AU - Salazar, Juan C.

PY - 2014

Y1 - 2014

N2 - Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete.

AB - Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete.

KW - Borrelia burgdorferi

KW - Innate immunity

KW - Lyme disease

KW - Phagosomal signaling

KW - Toll-like receptors

UR - https://www.scopus.com/pages/publications/84907164885

UR - https://www.scopus.com/pages/publications/84907164885#tab=citedBy

U2 - 10.3389/fcimb.2014.00055

DO - 10.3389/fcimb.2014.00055

M3 - Review article

C2 - 24904837

AN - SCOPUS:84907164885

SN - 2235-2988

VL - 4

JO - Frontiers in Cellular and Infection Microbiology

JF - Frontiers in Cellular and Infection Microbiology

IS - MAY

M1 - 55

ER -

Phagosomal TLR signaling upon Borrelia burgdorferi infection

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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