Abstract
Adrenoceptors (ARs) consist of nine subtypes (α1A-, α1B-, α1D-, β1-, β 2-, β3-, α2A-, α 2B- and α2C-AR), which are involved in a wide spectrum of physiological functions and are the site of action for a considerable percentage of currently prescribed therapeutics. With the exception of α1D, all AR subtypes are polymorphic with genetic variations in the coding and non-coding regions. This review discusses the biochemical consequences of these genetic variations and their impact in receptor function, disease pathophysiology, and drug response.Pharmacogenomic principles that have been discovered are also discussed. 2004
| Original language | English |
|---|---|
| Pages (from-to) | 803-817 |
| Number of pages | 15 |
| Journal | Pharmacogenomics |
| Volume | 5 |
| Issue number | 7 |
| DOIs | |
| State | Published - Oct 2004 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Molecular Medicine
- Genetics
- Pharmacology
Keywords
- Adrenoceptor
- Pharmacogenomics
- Polymorphism
- Polymorphism combination
- Receptor haplotypes
- Receptors, Adrenergic/genetics
- Animals
- Humans
- Pharmacogenetics/methods
- Genetic Variation/genetics
- Polymorphism, Genetic
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