Abstract
Pixantrone isa synthetic aza-anthracenedione analog. It intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. Pixantrone was developed to as a safer version of the anthracyclines and anthracenediones. Pixantrone displays no measurable cardiotoxicity as compared to mitoxantrone, its parent compound, or to other anthracyclines at equi-effective doses .... © 2008
| Original language | English |
|---|---|
| Title of host publication | xPharm |
| Subtitle of host publication | The Comprehensive Pharmacology Reference |
| Publisher | Elsevier Inc. |
| Pages | 1-4 |
| Number of pages | 4 |
| ISBN (Print) | 9780080552323 |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- General Pharmacology, Toxicology and Pharmaceutics
Disciplines
- Medicine and Health Sciences
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