Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy

Sarah J. Lincoln; Owen A. Ross; Nicole M. Milkovic; Dennis W. Dickson; Alex Rajput; Christopher A. Robinson; Spiridon Papapetropoulos; Deborah C. Mash; Matthew J. Farrer

doi:10.1016/j.parkreldis.2006.12.005

Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy

Sarah J. Lincoln
, Owen A. Ross
, Nicole M. Milkovic
, Dennis W. Dickson
, Alex Rajput
, Christopher A. Robinson
, Spiridon Papapetropoulos
, Deborah C. Mash
, Matthew J. Farrer

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the α-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.

Original language	English
Pages (from-to)	340-342
Number of pages	3
Journal	Parkinsonism and Related Disorders
Volume	13
Issue number	6
DOIs	https://doi.org/10.1016/j.parkreldis.2006.12.005
State	Published - Aug 2007
Externally published	Yes

ASJC Scopus Subject Areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

Keywords

α-Synuclein
Genomic multiplication
Multiple system atrophy
Quantitative PCR

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10.1016/j.parkreldis.2006.12.005

Cite this

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title = "Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy",

abstract = "Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the α-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.",

keywords = "α-Synuclein, Genomic multiplication, Multiple system atrophy, Quantitative PCR",

author = "Lincoln, \{Sarah J.\} and Ross, \{Owen A.\} and Milkovic, \{Nicole M.\} and Dickson, \{Dennis W.\} and Alex Rajput and Robinson, \{Christopher A.\} and Spiridon Papapetropoulos and Mash, \{Deborah C.\} and Farrer, \{Matthew J.\}",

year = "2007",

month = aug,

doi = "10.1016/j.parkreldis.2006.12.005",

language = "English",

volume = "13",

pages = "340--342",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",

publisher = "Elsevier Ltd",

number = "6",

}

TY - JOUR

T1 - Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy

AU - Lincoln, Sarah J.

AU - Ross, Owen A.

AU - Milkovic, Nicole M.

AU - Dickson, Dennis W.

AU - Rajput, Alex

AU - Robinson, Christopher A.

AU - Papapetropoulos, Spiridon

AU - Mash, Deborah C.

AU - Farrer, Matthew J.

PY - 2007/8

Y1 - 2007/8

N2 - Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the α-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.

AB - Multiple system atrophy (MSA) is by nature a 'sporadic' disease with no evidence of familial aggregation observed. However, the α-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered.

KW - α-Synuclein

KW - Genomic multiplication

KW - Multiple system atrophy

KW - Quantitative PCR

UR - https://www.scopus.com/pages/publications/34547657291

UR - https://www.scopus.com/pages/publications/34547657291#tab=citedBy

U2 - 10.1016/j.parkreldis.2006.12.005

DO - 10.1016/j.parkreldis.2006.12.005

M3 - Article

C2 - 17291816

AN - SCOPUS:34547657291

SN - 1353-8020

VL - 13

SP - 340

EP - 342

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

IS - 6

ER -

Quantitative PCR-based screening of α-synuclein multiplication in multiple system atrophy

Abstract

ASJC Scopus Subject Areas

Keywords

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