Rate and duration of stimulation: As a determinant of drug action on the CNS

L. X. Cubeddu

Rate and duration of stimulation: As a determinant of drug action on the CNS

L. X. Cubeddu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Evidence was presented to indicate that the rate and duration of stimulation of a specific neuronal group or its basal firing activity and firing pattern determine drug action. These in vitro and in vivo findings indicate that: the effects of drugs on the CNS vary depending on the basal status of activity of a specific neuronal target. The neuronal activity (firing rate and pattern) may be affected by physiological activity, disease and by drugs. It is envisaged that in the near future a priming drug may be given to modify neuronal firing pattern, in order to enhance the effects of a specific drug treatment.

Original language	English
Title of host publication	Recent advances in pharmacology and therapeutics
Subtitle of host publication	proceedings of the XII Latin-American Congress of Pharmacology and the III Inter-American Congress of Clinical Pharmacology and Therapeutics. ICS839
Editors	M. Velasco, A. Israel, E. Romero, H. Silva
Publisher	Elsevier Science Publishers B.V.
Pages	307-313
Number of pages	7
ISBN (Print)	0444811079, 9780444811073
State	Published - 1989
Externally published	Yes
Event	The XII Latin-American Congress of Pharmacology and the III Inter-American Congress of Clinical Pharmacology and Therapeutics - Caracas, VENEZUELA Duration: Oct 2 1988 → Oct 7 1988

Conference

Conference	The XII Latin-American Congress of Pharmacology and the III Inter-American Congress of Clinical Pharmacology and Therapeutics
City	Caracas, VENEZUELA
Period	10/2/88 → 10/7/88

ASJC Scopus Subject Areas

General Medicine

Cite this

Cubeddu, L. X. (1989). Rate and duration of stimulation: As a determinant of drug action on the CNS. In M. Velasco, A. Israel, E. Romero, & H. Silva (Eds.), Recent advances in pharmacology and therapeutics: proceedings of the XII Latin-American Congress of Pharmacology and the III Inter-American Congress of Clinical Pharmacology and Therapeutics. ICS839 (pp. 307-313). Elsevier Science Publishers B.V..

Rate and duration of stimulation: As a determinant of drug action on the CNS. / Cubeddu, L. X.
Recent advances in pharmacology and therapeutics: proceedings of the XII Latin-American Congress of Pharmacology and the III Inter-American Congress of Clinical Pharmacology and Therapeutics. ICS839. ed. / M. Velasco; A. Israel; E. Romero; H. Silva. Elsevier Science Publishers B.V., 1989. p. 307-313.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Cubeddu, LX 1989, Rate and duration of stimulation: As a determinant of drug action on the CNS. in M Velasco, A Israel, E Romero & H Silva (eds), Recent advances in pharmacology and therapeutics: proceedings of the XII Latin-American Congress of Pharmacology and the III Inter-American Congress of Clinical Pharmacology and Therapeutics. ICS839. Elsevier Science Publishers B.V., pp. 307-313, The XII Latin-American Congress of Pharmacology and the III Inter-American Congress of Clinical Pharmacology and Therapeutics, Caracas, VENEZUELA, 10/2/88.

Cubeddu LX. Rate and duration of stimulation: As a determinant of drug action on the CNS. In Velasco M, Israel A, Romero E, Silva H, editors, Recent advances in pharmacology and therapeutics: proceedings of the XII Latin-American Congress of Pharmacology and the III Inter-American Congress of Clinical Pharmacology and Therapeutics. ICS839. Elsevier Science Publishers B.V. 1989. p. 307-313

Cubeddu, L. X. / Rate and duration of stimulation : As a determinant of drug action on the CNS. Recent advances in pharmacology and therapeutics: proceedings of the XII Latin-American Congress of Pharmacology and the III Inter-American Congress of Clinical Pharmacology and Therapeutics. ICS839. editor / M. Velasco ; A. Israel ; E. Romero ; H. Silva. Elsevier Science Publishers B.V., 1989. pp. 307-313

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BT - Recent advances in pharmacology and therapeutics

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PB - Elsevier Science Publishers B.V.

Y2 - 2 October 1988 through 7 October 1988

ER -

Rate and duration of stimulation: As a determinant of drug action on the CNS

Abstract

Conference

ASJC Scopus Subject Areas

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