Redox regulation of stem cell mobilization

Istvan Lekli; Narasimman Gurusamy; Diptarka Ray; Arpad Tosaki; Dipak K. Das

doi:10.1139/Y09-102

Redox regulation of stem cell mobilization

Istvan Lekli
, Narasimman Gurusamy
, Diptarka Ray
, Arpad Tosaki
, Dipak K. Das

Research output: Contribution to journal › Review article › peer-review

Abstract

A growing body of evidence supposts the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)1α appears to play a significant role in their maintenance and homing mechanism.

Original language	English
Pages (from-to)	989-995
Number of pages	7
Journal	Canadian Journal of Physiology and Pharmacology
Volume	87
Issue number	12
DOIs	https://doi.org/10.1139/Y09-102
State	Published - Dec 2009
Externally published	Yes

ASJC Scopus Subject Areas

Physiology
Pharmacology
Physiology (medical)

Keywords

Cytokines
FoxO
Hematopoietic stem cells
HIP-1α
Redox signaling
SirT
Stem cell homing
Forkhead Transcription Factors/physiology
Oxidation-Reduction
Humans
Cytokines/physiology
Sirtuins/physiology
Signal Transduction/physiology
Animals
Hypoxia/physiopathology
DNA-(Apurinic or Apyrimidinic Site) Lyase/physiology
Cell Differentiation
Hematopoietic Stem Cell Mobilization

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10.1139/Y09-102

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title = "Redox regulation of stem cell mobilization",

abstract = "A growing body of evidence supposts the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)1α appears to play a significant role in their maintenance and homing mechanism. ",

keywords = "Cytokines, FoxO, Hematopoietic stem cells, HIP-1α, Redox signaling, SirT, Stem cell homing, Forkhead Transcription Factors/physiology, Oxidation-Reduction, Humans, Cytokines/physiology, Sirtuins/physiology, Signal Transduction/physiology, Animals, Hypoxia/physiopathology, DNA-(Apurinic or Apyrimidinic Site) Lyase/physiology, Cell Differentiation, Hematopoietic Stem Cell Mobilization",

author = "Istvan Lekli and Narasimman Gurusamy and Diptarka Ray and Arpad Tosaki and Das, \{Dipak K.\}",

year = "2009",

month = dec,

doi = "10.1139/Y09-102",

language = "English",

volume = "87",

pages = "989--995",

journal = "Canadian Journal of Physiology and Pharmacology",

issn = "0008-4212",

number = "12",

}

TY - JOUR

T1 - Redox regulation of stem cell mobilization

AU - Lekli, Istvan

AU - Gurusamy, Narasimman

AU - Ray, Diptarka

AU - Tosaki, Arpad

AU - Das, Dipak K.

PY - 2009/12

Y1 - 2009/12

N2 - A growing body of evidence supposts the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)1α appears to play a significant role in their maintenance and homing mechanism.

AB - A growing body of evidence supposts the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)1α appears to play a significant role in their maintenance and homing mechanism.

KW - Cytokines

KW - FoxO

KW - Hematopoietic stem cells

KW - HIP-1α

KW - Redox signaling

KW - SirT

KW - Stem cell homing

KW - Forkhead Transcription Factors/physiology

KW - Oxidation-Reduction

KW - Humans

KW - Cytokines/physiology

KW - Sirtuins/physiology

KW - Signal Transduction/physiology

KW - Animals

KW - Hypoxia/physiopathology

KW - DNA-(Apurinic or Apyrimidinic Site) Lyase/physiology

KW - Cell Differentiation

KW - Hematopoietic Stem Cell Mobilization

UR - https://www.scopus.com/pages/publications/76549105514

UR - https://www.scopus.com/pages/publications/76549105514#tab=citedBy

U2 - 10.1139/Y09-102

DO - 10.1139/Y09-102

M3 - Review article

C2 - 20029535

AN - SCOPUS:76549105514

SN - 0008-4212

VL - 87

SP - 989

EP - 995

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

IS - 12

ER -

Redox regulation of stem cell mobilization

Abstract

ASJC Scopus Subject Areas

Keywords

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