Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress.

A Simonson; A Naraine; S Maki; K Nugent; S Lepore; K Dawson-Scully

doi:10.17912/micropub.biology.001127

Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress.

A Simonson
, A Naraine
, S Maki
, K Nugent
, S Lepore
, K Dawson-Scully

Research output: Contribution to journal › Article › peer-review

Abstract

Resveratrol as well as natural products biosynthetically derived from it, have been shown to have protective effects against oxidative stress. However, these compounds possess poor druglike properties. At sub-nanomolar concentrations, a novel compound (RVM-6) inspired by a resveratrol natural product prolongs synaptic viability in neuromuscular junctions in <i>D. melanogaster</i> exposed to acute oxidative stress.

Original language	Undefined/Unknown
Journal	microPublication biology
DOIs	https://doi.org/10.17912/micropub.biology.001127
State	Published - Sep 3 2024

Funding

We wish to acknowledge the NIH (GM110651) for financial support. Supported by National Institutes of Health (United States) GM110651 to Salvatore Lepore, Ken Dawson-Scully.

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10.17912/micropub.biology.001127License: CC BY

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title = "Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress.",

abstract = "Resveratrol as well as natural products biosynthetically derived from it, have been shown to have protective effects against oxidative stress. However, these compounds possess poor druglike properties. At sub-nanomolar concentrations, a novel compound (RVM-6) inspired by a resveratrol natural product prolongs synaptic viability in neuromuscular junctions in D. melanogaster exposed to acute oxidative stress.",

author = "A Simonson and A Naraine and S Maki and K Nugent and S Lepore and K Dawson-Scully",

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T1 - Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress.

AU - Simonson, A

AU - Naraine, A

AU - Maki, S

AU - Nugent, K

AU - Lepore, S

AU - Dawson-Scully, K

PY - 2024/9/3

Y1 - 2024/9/3

N2 - Resveratrol as well as natural products biosynthetically derived from it, have been shown to have protective effects against oxidative stress. However, these compounds possess poor druglike properties. At sub-nanomolar concentrations, a novel compound (RVM-6) inspired by a resveratrol natural product prolongs synaptic viability in neuromuscular junctions in D. melanogaster exposed to acute oxidative stress.

AB - Resveratrol as well as natural products biosynthetically derived from it, have been shown to have protective effects against oxidative stress. However, these compounds possess poor druglike properties. At sub-nanomolar concentrations, a novel compound (RVM-6) inspired by a resveratrol natural product prolongs synaptic viability in neuromuscular junctions in D. melanogaster exposed to acute oxidative stress.

UR - https://europepmc.org/articles/PMC11409061

U2 - 10.17912/micropub.biology.001127

DO - 10.17912/micropub.biology.001127

M3 - Article

C2 - 39296884

JO - microPublication biology

JF - microPublication biology

ER -

Resveratrol natural product inspired compound as a potent neuroprotectant against acute oxidative stress.

Abstract

Funding

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