TY - JOUR
T1 - "Retraction:Expression of the longevity proteins by both red and white wines and their cardioprotective components
AU - Mukherjee, Subhendu
AU - Lekli, Istvan
AU - Gurusamy, Narasimman
AU - Bertelli, Alberto A.A.
AU - Das, Dipak K.
PY - 2009/3/1
Y1 - 2009/3/1
N2 - Resveratrol increases longevity through SirT1, which is activated with NAD+ supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine > resveratrol > tyrosol > hydroxytyrosol > red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol > red wine > hydroxytyrosol > white wine > tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.
AB - Resveratrol increases longevity through SirT1, which is activated with NAD+ supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine > resveratrol > tyrosol > hydroxytyrosol > red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol > red wine > hydroxytyrosol > white wine > tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.
KW - Cardioprotection
KW - FoxO1
KW - Hydroxytyrosol
KW - Longevity
KW - PBEF
KW - Red wine
KW - Resveratrol
KW - SirT1
KW - Tyrosol
KW - White wine
UR - https://www.scopus.com/pages/publications/59249084680
UR - https://www.scopus.com/pages/publications/59249084680#tab=citedBy
U2 - 10.1016/j.freeradbiomed.2008.11.005
DO - 10.1016/j.freeradbiomed.2008.11.005
M3 - Article
C2 - 19071213
AN - SCOPUS:59249084680
SN - 0891-5849
VL - 46
SP - 573
EP - 578
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
IS - 5
ER -