Roles of Angiotensin III in the brain and periphery

Ann Tenneil O'Connor; Dhanush Haspula; Ahmed Z. Alanazi; Michelle A. Clark

doi:10.1016/j.peptides.2022.170802

Roles of Angiotensin III in the brain and periphery

Ann Tenneil O'Connor
, Dhanush Haspula
, Ahmed Z. Alanazi
, Michelle A. Clark

Research output: Contribution to journal › Review article › peer-review

Abstract

Angiotensin (Ang) III, a biologically active peptide of the renin angiotensin system (RAS) is predominantly known for its central effects on blood pressure. Our understanding of the RAS has evolved from the simplified, classical RAS, a hormonal system regulating blood pressure to a complex system affecting numerous biological processes. Ang II, the main RAS peptide has been widely studied, and its deleterious effects when overexpressed is well-documented. However, other components of the RAS such as Ang III are not well studied. This review examines the molecular and biological actions of Ang III and provides insight into Ang III's potential role in metabolic diseases.

Original language	English
Article number	170802
Journal	Peptides
Volume	153
DOIs	https://doi.org/10.1016/j.peptides.2022.170802
State	Published - Jul 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc.

ASJC Scopus Subject Areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

Keywords

Aminopeptidase A
Angiotensin II type 2 receptor
Angiotensin II type I receptor
Angiotensin III

Disciplines

Biochemistry
Endocrinology
Molecular and Cellular Neuroscience

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10.1016/j.peptides.2022.170802

Cite this

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title = "Roles of Angiotensin III in the brain and periphery",

abstract = "Angiotensin (Ang) III, a biologically active peptide of the renin angiotensin system (RAS) is predominantly known for its central effects on blood pressure. Our understanding of the RAS has evolved from the simplified, classical RAS, a hormonal system regulating blood pressure to a complex system affecting numerous biological processes. Ang II, the main RAS peptide has been widely studied, and its deleterious effects when overexpressed is well-documented. However, other components of the RAS such as Ang III are not well studied. This review examines the molecular and biological actions of Ang III and provides insight into Ang III's potential role in metabolic diseases.",

keywords = "Aminopeptidase A, Angiotensin II type 2 receptor, Angiotensin II type I receptor, Angiotensin III",

author = "O'Connor, \{Ann Tenneil\} and Dhanush Haspula and Alanazi, \{Ahmed Z.\} and Clark, \{Michelle A.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = jul,

doi = "10.1016/j.peptides.2022.170802",

language = "English",

volume = "153",

journal = "Peptides",

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TY - JOUR

T1 - Roles of Angiotensin III in the brain and periphery

AU - O'Connor, Ann Tenneil

AU - Haspula, Dhanush

AU - Alanazi, Ahmed Z.

AU - Clark, Michelle A.

PY - 2022/7

Y1 - 2022/7

N2 - Angiotensin (Ang) III, a biologically active peptide of the renin angiotensin system (RAS) is predominantly known for its central effects on blood pressure. Our understanding of the RAS has evolved from the simplified, classical RAS, a hormonal system regulating blood pressure to a complex system affecting numerous biological processes. Ang II, the main RAS peptide has been widely studied, and its deleterious effects when overexpressed is well-documented. However, other components of the RAS such as Ang III are not well studied. This review examines the molecular and biological actions of Ang III and provides insight into Ang III's potential role in metabolic diseases.

AB - Angiotensin (Ang) III, a biologically active peptide of the renin angiotensin system (RAS) is predominantly known for its central effects on blood pressure. Our understanding of the RAS has evolved from the simplified, classical RAS, a hormonal system regulating blood pressure to a complex system affecting numerous biological processes. Ang II, the main RAS peptide has been widely studied, and its deleterious effects when overexpressed is well-documented. However, other components of the RAS such as Ang III are not well studied. This review examines the molecular and biological actions of Ang III and provides insight into Ang III's potential role in metabolic diseases.

KW - Aminopeptidase A

KW - Angiotensin II type 2 receptor

KW - Angiotensin II type I receptor

KW - Angiotensin III

UR - https://www.scopus.com/pages/publications/85129932734

UR - https://www.scopus.com/pages/publications/85129932734#tab=citedBy

U2 - 10.1016/j.peptides.2022.170802

DO - 10.1016/j.peptides.2022.170802

M3 - Review article

C2 - 35489649

AN - SCOPUS:85129932734

SN - 0196-9781

VL - 153

JO - Peptides

JF - Peptides

M1 - 170802

ER -

Roles of Angiotensin III in the brain and periphery

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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