Abstract
Previous experiments suggest that sleep deprivation (SD) is associated with growth hormone-releasing hormone (GHRH) release and that GHRH promotes sleep via intrahypothalamic sites of action. Binding of [His1, 125I-Tyr10, Nle27]hGHRH(1-32) amide and GHRH receptor (GHRH-R) mRNA levels were determined in the hypothalamus and pituitary of rats subjected to 8 h of SD and of undisturbed control rats. The characteristics of the hypothalamic GHRH binding sites differed from those of the pituitary. High affinity GHRH binding and GHRH-R mRNA levels decreased by 50% in the hypothalamus of SD rats, whereas there were no alterations in the pituitary. The results demonstrate that GHRH-Rs exist in the hypothalamus and they respond differently to SD than the GHRH-Rs in the pituitary. The SD-induced changes are explained by down-regulation of the hypothalamic GHRH-Rs induced by GHRH release during and after SD.
| Original language | English |
|---|---|
| Pages (from-to) | 69-72 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 329 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 23 2002 |
| Externally published | Yes |
Bibliographical note
Copyright 2002 Elsevier Science Ireland Ltd.ASJC Scopus Subject Areas
- General Neuroscience
Keywords
- Brain
- Growth hormone-releasing hormone receptor
- Messenger RNA
- Pituitary
- Sleep
- Somatotropic axis
- Growth Hormone-Releasing Hormone/analogs & derivatives
- Gene Expression/physiology
- Pituitary-Adrenal System/metabolism
- Rats
- Male
- Rats, Sprague-Dawley
- Sleep Deprivation/metabolism
- Animals
- Receptors, Pituitary Hormone-Regulating Hormone/genetics
- Hypothalamo-Hypophyseal System/metabolism
- RNA, Messenger/analysis
- Receptors, Neuropeptide/genetics
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