Smart stimuli-responsive biopolymeric nanomedicines for targeted therapy of solid tumors

Marziyeh Fathi; Elaheh Dalir Abdolahinia; Jaleh Barar; Yadollah Omidi

doi:10.2217/nnm-2020-0146

Smart stimuli-responsive biopolymeric nanomedicines for targeted therapy of solid tumors

Marziyeh Fathi
, Elaheh Dalir Abdolahinia
, Jaleh Barar
, Yadollah Omidi

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Solid tumors form a permissive microenvironment with irregular features, including high pressured tumor interstitial fluid with acidic pH, co-Adaptation of cancer cells with other cells like the immune system cells, abnormal metabolism and anomalous overexpression of various pieces of molecular machinery. The functional expressions of several oncomarkers in different solid tumors have led to the development of targeted drug-delivery systems (DDSs). As a new class of DDSs, stimuli-responsive nanomedicines (SRNMs) have been developed using advanced nanobiomaterials such as biopolymers that show excellent biocompatibility with low inherent immunogenicity. In this review, we aim to overview different types of SRNMs, present deep insights into the stimuli-responsive biopolymers and discuss the most up-To-date progress in the design and development of SRNMs used as advanced DDSs for targeted therapy of cancer.

Original language	English
Pages (from-to)	2171-2200
Number of pages	30
Journal	Nanomedicine
Volume	15
Issue number	22
DOIs	https://doi.org/10.2217/nnm-2020-0146
State	Published - Sep 2020

Bibliographical note

Publisher Copyright:
© 2020 Future Medicine Ltd.

Funding

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

ASJC Scopus Subject Areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science

Keywords

biopolymers
cancer
drug-delivery systems
multifunctional nanomedicines
solid tumor
stimuli-responsive nanosystems
targeted therapy

Disciplines

Biomedical Engineering and Bioengineering
Materials Science and Engineering
Medicine and Health Sciences

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10.2217/nnm-2020-0146

Cite this

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title = "Smart stimuli-responsive biopolymeric nanomedicines for targeted therapy of solid tumors",

abstract = "Solid tumors form a permissive microenvironment with irregular features, including high pressured tumor interstitial fluid with acidic pH, co-Adaptation of cancer cells with other cells like the immune system cells, abnormal metabolism and anomalous overexpression of various pieces of molecular machinery. The functional expressions of several oncomarkers in different solid tumors have led to the development of targeted drug-delivery systems (DDSs). As a new class of DDSs, stimuli-responsive nanomedicines (SRNMs) have been developed using advanced nanobiomaterials such as biopolymers that show excellent biocompatibility with low inherent immunogenicity. In this review, we aim to overview different types of SRNMs, present deep insights into the stimuli-responsive biopolymers and discuss the most up-To-date progress in the design and development of SRNMs used as advanced DDSs for targeted therapy of cancer.",

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note = "Publisher Copyright: {\textcopyright} 2020 Future Medicine Ltd.",

year = "2020",

month = sep,

doi = "10.2217/nnm-2020-0146",

language = "English",

volume = "15",

pages = "2171--2200",

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AU - Fathi, Marziyeh

AU - Abdolahinia, Elaheh Dalir

AU - Barar, Jaleh

AU - Omidi, Yadollah

PY - 2020/9

Y1 - 2020/9

N2 - Solid tumors form a permissive microenvironment with irregular features, including high pressured tumor interstitial fluid with acidic pH, co-Adaptation of cancer cells with other cells like the immune system cells, abnormal metabolism and anomalous overexpression of various pieces of molecular machinery. The functional expressions of several oncomarkers in different solid tumors have led to the development of targeted drug-delivery systems (DDSs). As a new class of DDSs, stimuli-responsive nanomedicines (SRNMs) have been developed using advanced nanobiomaterials such as biopolymers that show excellent biocompatibility with low inherent immunogenicity. In this review, we aim to overview different types of SRNMs, present deep insights into the stimuli-responsive biopolymers and discuss the most up-To-date progress in the design and development of SRNMs used as advanced DDSs for targeted therapy of cancer.

AB - Solid tumors form a permissive microenvironment with irregular features, including high pressured tumor interstitial fluid with acidic pH, co-Adaptation of cancer cells with other cells like the immune system cells, abnormal metabolism and anomalous overexpression of various pieces of molecular machinery. The functional expressions of several oncomarkers in different solid tumors have led to the development of targeted drug-delivery systems (DDSs). As a new class of DDSs, stimuli-responsive nanomedicines (SRNMs) have been developed using advanced nanobiomaterials such as biopolymers that show excellent biocompatibility with low inherent immunogenicity. In this review, we aim to overview different types of SRNMs, present deep insights into the stimuli-responsive biopolymers and discuss the most up-To-date progress in the design and development of SRNMs used as advanced DDSs for targeted therapy of cancer.

KW - biopolymers

KW - cancer

KW - drug-delivery systems

KW - multifunctional nanomedicines

KW - solid tumor

KW - stimuli-responsive nanosystems

KW - targeted therapy

UR - https://www.scopus.com/pages/publications/85091595453

UR - https://www.scopus.com/pages/publications/85091595453#tab=citedBy

U2 - 10.2217/nnm-2020-0146

DO - 10.2217/nnm-2020-0146

M3 - Review article

C2 - 32912045

AN - SCOPUS:85091595453

SN - 1743-5889

VL - 15

SP - 2171

EP - 2200

JO - Nanomedicine

JF - Nanomedicine

IS - 22

ER -

Smart stimuli-responsive biopolymeric nanomedicines for targeted therapy of solid tumors

Abstract

Bibliographical note

Funding

ASJC Scopus Subject Areas

Keywords

Disciplines

Access to Document

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