TY - JOUR
T1 - Solubility of benzodiazepines in polyethylene glycol 200 + water mixtures at 303.2 K
AU - Jouyban, Abolghasem
AU - Shokri, Javad
AU - Barzegar-Jalali, Mohammad
AU - Hassanzadeh, Davoud
AU - Acree, William E.
AU - Ghafourian, Taravat
AU - Nokhodchi, Ali
PY - 2010/1/14
Y1 - 2010/1/14
N2 - Experimental solubilities of chlordiazepoxide, diazepam, and lorazepam in polyethylene glycol 200 (PEG 200) + water mixtures at 303.2 K were reported. The solubility of each drug increased exponentially with the addition of PEG 200 and reached the maximum value in neat PEG 200. The Jouyban-Acree model was used to mathematically describe the experimental data, and the solubilities were predicted using a previously trained version of the Jouyban-Acree model for PEG + water mixtures and the solubility data in monosolvents. The overall mean relative deviations of the models were 3.7% and 18.3%, respectively, for the fitted model and the trained version.
AB - Experimental solubilities of chlordiazepoxide, diazepam, and lorazepam in polyethylene glycol 200 (PEG 200) + water mixtures at 303.2 K were reported. The solubility of each drug increased exponentially with the addition of PEG 200 and reached the maximum value in neat PEG 200. The Jouyban-Acree model was used to mathematically describe the experimental data, and the solubilities were predicted using a previously trained version of the Jouyban-Acree model for PEG + water mixtures and the solubility data in monosolvents. The overall mean relative deviations of the models were 3.7% and 18.3%, respectively, for the fitted model and the trained version.
UR - https://www.scopus.com/pages/publications/75449114661
UR - https://www.scopus.com/pages/publications/75449114661#tab=citedBy
U2 - 10.1021/je900330p
DO - 10.1021/je900330p
M3 - Article
AN - SCOPUS:75449114661
SN - 0021-9568
VL - 55
SP - 519
EP - 522
JO - Journal of Chemical and Engineering Data
JF - Journal of Chemical and Engineering Data
IS - 1
ER -