Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K

Abolghasem Jouyban; Javad Shokri; Mohammad Barzegar Jalali; Davoud Hassanzadeh; William E. Acree; Taravat Ghafourian; Ali Nokhodchi

doi:10.1021/je900200k

Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K

Abolghasem Jouyban
, Javad Shokri
, Mohammad Barzegar Jalali
, Davoud Hassanzadeh
, William E. Acree
, Taravat Ghafourian
, Ali Nokhodchi

Research output: Contribution to journal › Article › peer-review

Abstract

Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %,21.9 % and 19.3 %,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures.

Original language	English
Pages (from-to)	2142-2145
Number of pages	4
Journal	Journal of Chemical and Engineering Data
Volume	54
Issue number	7
DOIs	https://doi.org/10.1021/je900200k
State	Published - Jul 9 2009
Externally published	Yes

ASJC Scopus Subject Areas

General Chemistry
General Chemical Engineering

Access to Document

10.1021/je900200k

Cite this

@article{46f7a5bc5f9449b09dc34f08345f1ef7,

title = "Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K",

abstract = "Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 \% of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 \%,21.9 \% and 19.3 \%,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures. ",

author = "Abolghasem Jouyban and Javad Shokri and Jalali, \{Mohammad Barzegar\} and Davoud Hassanzadeh and Acree, \{William E.\} and Taravat Ghafourian and Ali Nokhodchi",

year = "2009",

month = jul,

day = "9",

doi = "10.1021/je900200k",

language = "English",

volume = "54",

pages = "2142--2145",

journal = "Journal of Chemical and Engineering Data",

issn = "0021-9568",

number = "7",

}

TY - JOUR

T1 - Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K

AU - Jouyban, Abolghasem

AU - Shokri, Javad

AU - Jalali, Mohammad Barzegar

AU - Hassanzadeh, Davoud

AU - Acree, William E.

AU - Ghafourian, Taravat

AU - Nokhodchi, Ali

PY - 2009/7/9

Y1 - 2009/7/9

N2 - Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %,21.9 % and 19.3 %,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures.

AB - Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam,and lorazepam) in ethanol+water mixtures at 303.2 K are reported.The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol.The Jouyban-Acree model was used to fit the experimental data,and the solubilities were reproduced using previously trained version of the Jouyban-Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %,21.9 % and 19.3 %,respectively,for the fitted model,the trained version for ethanol+water mixtures and generally trained version for various organic solvents+water mixtures.

UR - https://www.scopus.com/pages/publications/67749120584

UR - https://www.scopus.com/pages/publications/67749120584#tab=citedBy

U2 - 10.1021/je900200k

DO - 10.1021/je900200k

M3 - Article

AN - SCOPUS:67749120584

SN - 0021-9568

VL - 54

SP - 2142

EP - 2145

JO - Journal of Chemical and Engineering Data

JF - Journal of Chemical and Engineering Data

IS - 7

ER -

Solubility of chlordiazepoxide,diazepam,and lorazepam in ethanol+water mixtures at 303.2 K

Abstract

ASJC Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this