Abstract
Aim: Nanocomposites of graphene oxide (GO) loaded with PEGylated superparamagnetic iron oxide nanoparticles and grafted with methotrexate and stimuli-responsive linkers (GO-SPION-MTX) were developed for photothermal and chemotherapy of breast cancer. Methods: PEGylated SPIONs were synthesized and conjugated with chemotherapeutic targeting agent MTX, which were then loaded on GO to prepare GO-SPION-MTX nanocomposites. To evaluate the photothermal effect of the nanocomposites, they were examined in breast cancer cell lines with low doses of near-infrared (NIR) laser radiation with/without acetazolamide. Results: The GO-SPION-MTX nanocomposites were found to be internalized by the folate-receptor-positive cancer cells and induce high cytotoxicity on exposure to NIR laser rays. Conclusion: Our findings suggest that the GO-SPION-MTX nanocomposite can potentially be used as a multimodal nanomedicine/theranostic against breast cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 2155-2174 |
| Number of pages | 20 |
| Journal | Nanomedicine |
| Volume | 16 |
| Issue number | 24 |
| DOIs | |
| State | Published - Sep 27 2021 |
Bibliographical note
Publisher Copyright:© 2021 Future Medicine Ltd.
Funding
This research was supported by Research Vice-Chancellor of Tabriz University of Medical Sciences (no. 130) and the Research Center for Pharmaceutical Nanotechnology at Tabriz University of Medical Sciences. Y Omidi is a member of the Nanomedicine Editorial Board. They were not involved in any editorial decisions related to the publication of this article, and all author details were blinded to the article’s peer reviewers as per the journal’s double-blind peer-review policy. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
ASJC Scopus Subject Areas
- Bioengineering
- Medicine (miscellaneous)
- Biomedical Engineering
- General Materials Science
Keywords
- acetazolamide
- breast cancer
- graphene oxide
- nanomedicine
- photothermal therapy
- stimuli-responsive
- theranostics
Disciplines
- Biomedical Engineering and Bioengineering
- Medicine and Health Sciences
- Materials Science and Engineering
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