Study of the relationship between α_2B-adrenergic receptor polymorphism and restenosis following coronary angioplasty: Preliminary report

We investigated whether the polymorphism of the α2B- adrenergic receptor gene was associated with the risk of restenosis in 96 Greek coronary artery disease patients undergoing coronary angioplasty and stent implantation. The end-point of the current study was the incidence of restenosis at seven months of clinical follow-up. For the comparison of genotype frequency a control group of 83 healthy individuals was also studied. Seventy of 96 patients had the insertion/insertion genotype, 23/96 had the insertion/deletion genotype and 3/96 had the deletion/deletion genotype; the frequency distribution was not different from that of the healthy control subjects. Restenosis occurred in 15 (15.6%) of the 96 patients. In the population studied, α2B-adrenoreceptar polymorphisms were not found to predispose patients to an increased incidence of restenosis. This finding should be considered as preliminary, taking into account the small number of studied patients and the rarity of the deletion/deletion genotype.