Abstract
Superporous hydrogels (SPHs) are cross-linked hydrophilic water-swellable polymers, which, regardless of their size in a dry state, can reach their equilibrium swelling capacity in minutes. A few generations of these porous hydrogels have been evolved to address the needs of different drug delivery applications. This chapter reviews the different aspects of SPH materials, including their synthesis, properties, generations, scale up, and safety. From the stability standpoint, the identity, purity, and potency of SPH products are discussed in detail. The chapter discusses SPH applications in drug delivery, including gastric retention and peroral intestinal absorption. The chapter concludes with the potential use of SPHs as a diet aid, superdisintegrant, and cell scaffolding.
| Original language | English |
|---|---|
| Title of host publication | Comprehensive Biomaterials II |
| Publisher | Elsevier |
| Pages | 688-704 |
| Number of pages | 17 |
| ISBN (Electronic) | 9780081006924 |
| ISBN (Print) | 9780081006917 |
| DOIs | |
| State | Published - Jan 1 2017 |
Bibliographical note
Publisher Copyright:© 2017 Elsevier Ltd All rights reserved.
ASJC Scopus Subject Areas
- General Engineering
- General Materials Science
Keywords
- Applications
- Cell scaffolding
- Diet aid
- Drug delivery
- Gastric retention drug delivery
- Hydrogels
- Mechanical strength
- Peroral intestinal drug delivery
- Safety
- Scale up
- Stability
- Superdisintegrant
- Superporous hydrogels
- Swelling capacity
- Swelling rate
- Synthesis