Abstract
Owing to the specific molecular structure of surfactants, these compounds can penetrate into the stratum corneum (SC) and thereby increase the transdermal absorption of drugs. As a result, surfactants are some of the most widely used enhancers in transdermal drug delivery formulations/systems. Starting with an introduction into the chemical structure and physicochemical characteristics of surfactants, this chapter is focused on the application of various surfactants for increasing the skin absorption of drugs and the mechanisms involved in this process. In particular, application of various ionic and nonionic surfactants and synergism with physical and chemical permeation enhancement methods such as electrophoresis have been discussed, and key publications in this subject area have been introduced.
| Original language | English |
|---|---|
| Title of host publication | Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement |
| Subtitle of host publication | Modification of the Stratum Corneum |
| Publisher | Springer Berlin Heidelberg |
| Pages | 207-230 |
| Number of pages | 24 |
| ISBN (Electronic) | 9783662470398 |
| ISBN (Print) | 9783662470381 |
| DOIs | |
| State | Published - Jan 1 2015 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© Springer-Verlag Berlin Heidelberg 2015.
ASJC Scopus Subject Areas
- General Medicine
- General Pharmacology, Toxicology and Pharmaceutics
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