Swelling and mechanical properties of modified HEMA-based superporous hydrogels

Hossein Omidian; Kinam Park; Umadevi Kandalam; Jose G. Rocca

doi:10.1177/0883911510375175

Swelling and mechanical properties of modified HEMA-based superporous hydrogels

Hossein Omidian
, Kinam Park
, Umadevi Kandalam
, Jose G. Rocca

Research output: Contribution to journal › Article › peer-review

Abstract

Superporous hydrogels (SPHs), based on poly(2-hydroxyethyl methacrylate) (PHEMA), were prepared by adding minute amounts of an ion-complexable hydrophilic acrylic acid. PHEMA SPHs are generally strong, but their swelling is minimal. To improve the swelling, different poly(HEMA-co-acrylic acid) hydrogels were polymerized and crosslinked, then physically treated with divalent calcium and trivalent aluminum cations. The incorporation of acrylic acid copolymer into the SPH, followed by crosslinking of the copolymer with calcium or aluminum ions produced SPHs with improved swelling and strength. Cells in the presence of hydrogel showed high viability indicating the absence of cytotoxicity and stimulatory effect.

Original language	English
Pages (from-to)	483-497
Number of pages	15
Journal	Journal of Bioactive and Compatible Polymers
Volume	25
Issue number	5
DOIs	https://doi.org/10.1177/0883911510375175
State	Published - Sep 2010

ASJC Scopus Subject Areas

Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

Keywords

2-hydroxyethyl methacrylate
ionotropic gelation
physical crosslinking
superporous hydrogel
toxicity.

Disciplines

Biomaterials
Polymer and Organic Materials
Materials Chemistry

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10.1177/0883911510375175

Cite this

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title = "Swelling and mechanical properties of modified HEMA-based superporous hydrogels",

abstract = "Superporous hydrogels (SPHs), based on poly(2-hydroxyethyl methacrylate) (PHEMA), were prepared by adding minute amounts of an ion-complexable hydrophilic acrylic acid. PHEMA SPHs are generally strong, but their swelling is minimal. To improve the swelling, different poly(HEMA-co-acrylic acid) hydrogels were polymerized and crosslinked, then physically treated with divalent calcium and trivalent aluminum cations. The incorporation of acrylic acid copolymer into the SPH, followed by crosslinking of the copolymer with calcium or aluminum ions produced SPHs with improved swelling and strength. Cells in the presence of hydrogel showed high viability indicating the absence of cytotoxicity and stimulatory effect.",

keywords = "2-hydroxyethyl methacrylate, ionotropic gelation, physical crosslinking, superporous hydrogel, toxicity.",

author = "Hossein Omidian and Kinam Park and Umadevi Kandalam and Rocca, \{Jose G.\}",

year = "2010",

month = sep,

doi = "10.1177/0883911510375175",

language = "English",

volume = "25",

pages = "483--497",

journal = "Journal of Bioactive and Compatible Polymers",

issn = "0883-9115",

number = "5",

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TY - JOUR

T1 - Swelling and mechanical properties of modified HEMA-based superporous hydrogels

AU - Omidian, Hossein

AU - Park, Kinam

AU - Kandalam, Umadevi

AU - Rocca, Jose G.

PY - 2010/9

Y1 - 2010/9

N2 - Superporous hydrogels (SPHs), based on poly(2-hydroxyethyl methacrylate) (PHEMA), were prepared by adding minute amounts of an ion-complexable hydrophilic acrylic acid. PHEMA SPHs are generally strong, but their swelling is minimal. To improve the swelling, different poly(HEMA-co-acrylic acid) hydrogels were polymerized and crosslinked, then physically treated with divalent calcium and trivalent aluminum cations. The incorporation of acrylic acid copolymer into the SPH, followed by crosslinking of the copolymer with calcium or aluminum ions produced SPHs with improved swelling and strength. Cells in the presence of hydrogel showed high viability indicating the absence of cytotoxicity and stimulatory effect.

AB - Superporous hydrogels (SPHs), based on poly(2-hydroxyethyl methacrylate) (PHEMA), were prepared by adding minute amounts of an ion-complexable hydrophilic acrylic acid. PHEMA SPHs are generally strong, but their swelling is minimal. To improve the swelling, different poly(HEMA-co-acrylic acid) hydrogels were polymerized and crosslinked, then physically treated with divalent calcium and trivalent aluminum cations. The incorporation of acrylic acid copolymer into the SPH, followed by crosslinking of the copolymer with calcium or aluminum ions produced SPHs with improved swelling and strength. Cells in the presence of hydrogel showed high viability indicating the absence of cytotoxicity and stimulatory effect.

KW - 2-hydroxyethyl methacrylate

KW - ionotropic gelation

KW - physical crosslinking

KW - superporous hydrogel

KW - toxicity.

UR - https://www.scopus.com/pages/publications/77956308642

UR - https://www.scopus.com/pages/publications/77956308642#tab=citedBy

U2 - 10.1177/0883911510375175

DO - 10.1177/0883911510375175

M3 - Article

AN - SCOPUS:77956308642

SN - 0883-9115

VL - 25

SP - 483

EP - 497

JO - Journal of Bioactive and Compatible Polymers

JF - Journal of Bioactive and Compatible Polymers

IS - 5

ER -

Swelling and mechanical properties of modified HEMA-based superporous hydrogels

Abstract

ASJC Scopus Subject Areas

Keywords

Disciplines

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