Abstract
Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog.
| Original language | English |
|---|---|
| Pages (from-to) | 425-439 |
| Number of pages | 15 |
| Journal | Mini-Reviews in Medicinal Chemistry |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2005 |
| Externally published | Yes |
ASJC Scopus Subject Areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Cancer Research
Keywords
- Camptothecin
- Homocamptothecin
- Pharmacology
- Silatecan
- Synthesis
Disciplines
- Molecular Biology
- Pharmacology
- Pharmaceutics and Drug Design
- Cancer Biology
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