Synthesis, characterization, DNA binding and cleavage studies of chiral Ru(II) salen complexes.

N U Khan; Naushira Pandya; R I Kureshy; S H Abdi; S Agrawal; H C Bajaj; J Pandya; A Gupte

doi:10.1016/j.saa.2009.05.016

Synthesis, characterization, DNA binding and cleavage studies of chiral Ru(II) salen complexes.

N U Khan
, Naushira Pandya
, R I Kureshy
, S H Abdi
, S Agrawal
, H C Bajaj
, J Pandya
, A Gupte

Research output: Contribution to journal › Article › peer-review

Abstract

Interaction of chiral Ru(II) salen complexes (S)-1 and (R)-1 with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, CD measurements, thermal denaturation study and cleavage studies by agarose gel electrophoresis. The DNA binding affinity of (S)-1 (6.25 × 103 M-1) was found to be greater than (R)-1 (3.0 × 103 M-1). The antimicrobial studies of these complexes on five different gram (+)/(-) bacteria and three different fungal organisms showed selective inhibition of the growth of gram (+) bacteria and were not affective against gram (-) and fungal organisms. Further, the (S)-1 enantiomer inhibited the growth of organisms to a greater extent as compared to (R)-1 enantiomer. © 2009 Elsevier B.V. All rights reserved.

Original language	American English
Pages (from-to)	113-119
Number of pages	7
Journal	Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Volume	74
Issue number	1
DOIs	https://doi.org/10.1016/j.saa.2009.05.016
State	Published - Sep 1 2009

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Medical Specialties
Medicine and Health Sciences
Osteopathic Medicine and Osteopathy

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title = "Synthesis, characterization, DNA binding and cleavage studies of chiral Ru(II) salen complexes.",

abstract = "Interaction of chiral Ru(II) salen complexes (S)-1 and (R)-1 with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, CD measurements, thermal denaturation study and cleavage studies by agarose gel electrophoresis. The DNA binding affinity of (S)-1 (6.25 × 103 M-1) was found to be greater than (R)-1 (3.0 × 103 M-1). The antimicrobial studies of these complexes on five different gram (+)/(-) bacteria and three different fungal organisms showed selective inhibition of the growth of gram (+) bacteria and were not affective against gram (-) and fungal organisms. Further, the (S)-1 enantiomer inhibited the growth of organisms to a greater extent as compared to (R)-1 enantiomer. {\textcopyright} 2009 Elsevier B.V. All rights reserved.",

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T1 - Synthesis, characterization, DNA binding and cleavage studies of chiral Ru(II) salen complexes.

AU - Khan, N U

AU - Pandya, Naushira

AU - Kureshy, R I

AU - Abdi, S H

AU - Agrawal, S

AU - Bajaj, H C

AU - Pandya, J

AU - Gupte, A

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Interaction of chiral Ru(II) salen complexes (S)-1 and (R)-1 with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, CD measurements, thermal denaturation study and cleavage studies by agarose gel electrophoresis. The DNA binding affinity of (S)-1 (6.25 × 103 M-1) was found to be greater than (R)-1 (3.0 × 103 M-1). The antimicrobial studies of these complexes on five different gram (+)/(-) bacteria and three different fungal organisms showed selective inhibition of the growth of gram (+) bacteria and were not affective against gram (-) and fungal organisms. Further, the (S)-1 enantiomer inhibited the growth of organisms to a greater extent as compared to (R)-1 enantiomer. © 2009 Elsevier B.V. All rights reserved.

AB - Interaction of chiral Ru(II) salen complexes (S)-1 and (R)-1 with Calf Thymus DNA (CT-DNA) was studied by absorption spectroscopy, competitive binding study, viscosity measurements, CD measurements, thermal denaturation study and cleavage studies by agarose gel electrophoresis. The DNA binding affinity of (S)-1 (6.25 × 103 M-1) was found to be greater than (R)-1 (3.0 × 103 M-1). The antimicrobial studies of these complexes on five different gram (+)/(-) bacteria and three different fungal organisms showed selective inhibition of the growth of gram (+) bacteria and were not affective against gram (-) and fungal organisms. Further, the (S)-1 enantiomer inhibited the growth of organisms to a greater extent as compared to (R)-1 enantiomer. © 2009 Elsevier B.V. All rights reserved.

UR - https://nsuworks.nova.edu/hpd_com_faculty_articles/1330

U2 - 10.1016/j.saa.2009.05.016

DO - 10.1016/j.saa.2009.05.016

M3 - Article

VL - 74

SP - 113

EP - 119

JO - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

JF - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

IS - 1

ER -

Synthesis, characterization, DNA binding and cleavage studies of chiral Ru(II) salen complexes.

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