The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain

Vickie I. Cook; Kevin L. Grove; Kathleen M. McMenamin; Michele R. Carter; Joseph W. Harding; Robert C. Speth

doi:10.1016/0006-8993(91)91254-X

The AT₂ angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain

Vickie I. Cook
, Kevin L. Grove
, Kathleen M. McMenamin
, Michele R. Carter
, Joseph W. Harding
, Robert C. Speth

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The angiotensin II receptor subtype-specific antagonists Dup 753 (AT1) and PD 123177 (AT2) were used to characterize the angiotensin II receptor subtypes present in 18 day gestation fetal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rat brain using in vitro receptor autoradiography. The AT2 subtype was predominant in the brain of both rat strains, even in areas that display predominantly the AT1 subtype in the adult rat brain.

Original language	English
Pages (from-to)	334-336
Number of pages	3
Journal	Brain Research
Volume	560
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)91254-X
State	Published - Sep 27 1991
Externally published	Yes

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Keywords

Angiotensin receptor
Brain
Rat fetus
Subtype

Access to Document

10.1016/0006-8993(91)91254-X

Cite this

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abstract = "The angiotensin II receptor subtype-specific antagonists Dup 753 (AT1) and PD 123177 (AT2) were used to characterize the angiotensin II receptor subtypes present in 18 day gestation fetal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rat brain using in vitro receptor autoradiography. The AT2 subtype was predominant in the brain of both rat strains, even in areas that display predominantly the AT1 subtype in the adult rat brain. ",

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AU - Grove, Kevin L.

AU - McMenamin, Kathleen M.

AU - Carter, Michele R.

AU - Harding, Joseph W.

AU - Speth, Robert C.

PY - 1991/9/27

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KW - Rat fetus

KW - Subtype

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