The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations

A. Nokhodchi; H. Nazemiyeh; T. Ghafourian; D. Hassan-Zadeh; H. Valizadeh; L. A.S. Bahary

doi:10.1016/S0014-827X(02)01298-3

The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations

A. Nokhodchi
, H. Nazemiyeh
, T. Ghafourian
, D. Hassan-Zadeh
, H. Valizadeh
, L. A.S. Bahary

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The influence of glycyrrhizin extracted from Glycyrrhiza glabra var. glandulifera (licorice roots) on the percutaneous absorption of diclofenac sodium from sodium carboxymethylcellulose (NaCMC) gels or oil-in-water (o/w) emulsion was investigated. Skin permeation experiments were carried out using excised abdominal rat skin. The results showed that the efficiency of glycyrrhizin as an enhancer agent is greater in gel formulations than it is in the emulsions. The enhancer with the concentration of 0.1% w/w in gel increased diclofenac sodium flux value to tenfold compared with the control gel.

Original language	English
Pages (from-to)	883-888
Number of pages	6
Journal	Farmaco
Volume	57
Issue number	11
DOIs	https://doi.org/10.1016/S0014-827X(02)01298-3
State	Published - Nov 2002
Externally published	Yes

ASJC Scopus Subject Areas

Pharmaceutical Science
Drug Discovery

Keywords

Diclofenac sodium
Enhancer
Glycyrrhizin
Release rate
Skin penetration

Access to Document

10.1016/S0014-827X(02)01298-3

Cite this

@article{6d851d9ec44045a9936e35871a00bfa4,

title = "The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations",

abstract = "The influence of glycyrrhizin extracted from Glycyrrhiza glabra var. glandulifera (licorice roots) on the percutaneous absorption of diclofenac sodium from sodium carboxymethylcellulose (NaCMC) gels or oil-in-water (o/w) emulsion was investigated. Skin permeation experiments were carried out using excised abdominal rat skin. The results showed that the efficiency of glycyrrhizin as an enhancer agent is greater in gel formulations than it is in the emulsions. The enhancer with the concentration of 0.1\% w/w in gel increased diclofenac sodium flux value to tenfold compared with the control gel. ",

keywords = "Diclofenac sodium, Enhancer, Glycyrrhizin, Release rate, Skin penetration",

author = "A. Nokhodchi and H. Nazemiyeh and T. Ghafourian and D. Hassan-Zadeh and H. Valizadeh and Bahary, \{L. A.S.\}",

year = "2002",

month = nov,

doi = "10.1016/S0014-827X(02)01298-3",

language = "English",

volume = "57",

pages = "883--888",

journal = "Farmaco",

issn = "0014-827X",

publisher = "Elsevier B.V.",

number = "11",

}

TY - JOUR

T1 - The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations

AU - Nokhodchi, A.

AU - Nazemiyeh, H.

AU - Ghafourian, T.

AU - Hassan-Zadeh, D.

AU - Valizadeh, H.

AU - Bahary, L. A.S.

PY - 2002/11

Y1 - 2002/11

N2 - The influence of glycyrrhizin extracted from Glycyrrhiza glabra var. glandulifera (licorice roots) on the percutaneous absorption of diclofenac sodium from sodium carboxymethylcellulose (NaCMC) gels or oil-in-water (o/w) emulsion was investigated. Skin permeation experiments were carried out using excised abdominal rat skin. The results showed that the efficiency of glycyrrhizin as an enhancer agent is greater in gel formulations than it is in the emulsions. The enhancer with the concentration of 0.1% w/w in gel increased diclofenac sodium flux value to tenfold compared with the control gel.

AB - The influence of glycyrrhizin extracted from Glycyrrhiza glabra var. glandulifera (licorice roots) on the percutaneous absorption of diclofenac sodium from sodium carboxymethylcellulose (NaCMC) gels or oil-in-water (o/w) emulsion was investigated. Skin permeation experiments were carried out using excised abdominal rat skin. The results showed that the efficiency of glycyrrhizin as an enhancer agent is greater in gel formulations than it is in the emulsions. The enhancer with the concentration of 0.1% w/w in gel increased diclofenac sodium flux value to tenfold compared with the control gel.

KW - Diclofenac sodium

KW - Enhancer

KW - Glycyrrhizin

KW - Release rate

KW - Skin penetration

UR - https://www.scopus.com/pages/publications/0037210225

UR - https://www.scopus.com/pages/publications/0037210225#tab=citedBy

U2 - 10.1016/S0014-827X(02)01298-3

DO - 10.1016/S0014-827X(02)01298-3

M3 - Article

C2 - 12484536

AN - SCOPUS:0037210225

SN - 0014-827X

VL - 57

SP - 883

EP - 888

JO - Farmaco

JF - Farmaco

IS - 11

ER -

The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations

Abstract

ASJC Scopus Subject Areas

Keywords

Access to Document

Other files and links

Fingerprint

Cite this