The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19

Sepideh Zununi Vahed; Shahram Ghiyasvand; Ramin Tolouian; Hamid Noshad; Audrey Tolouian; Mohammadali Mohajel Shoja; Mohammadreza Ardalan

doi:10.34172/ipp.2020.27

The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19

Sepideh Zununi Vahed
, Shahram Ghiyasvand
, Ramin Tolouian
, Hamid Noshad
, Audrey Tolouian
, Mohammadali Mohajel Shoja
, Mohammadreza Ardalan

Research output: Contribution to journal › Article › peer-review

Abstract

Male gender is an obvious risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality rate is higher in men than women. Undoubtedly, gender-related behavioral factors, such as higher amounts of smoking, alcohol consumption, and biological differences in immune systems could make males more vulnerable. The role of androgen-responsive elements (AREs) of transmembrane serine proteases type II (TMPRSS2) gene as one of the major players of male dominancy in severe COVID-19 infection has been under appreciated and needs to be clarified.

Original language	English
Article number	e27
Journal	Immunopathologia Persa
Volume	6
Issue number	2
DOIs	https://doi.org/10.34172/ipp.2020.27
State	Published - Jul 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2020 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Immunology
Hematology
Immunology and Microbiology (miscellaneous)

Keywords

Androgen
COVID-19
Gender mortality
NCov-19
SARS-Cov-2
Serine protease
TMPRSS2

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10.34172/ipp.2020.27

Cite this

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abstract = "Male gender is an obvious risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality rate is higher in men than women. Undoubtedly, gender-related behavioral factors, such as higher amounts of smoking, alcohol consumption, and biological differences in immune systems could make males more vulnerable. The role of androgen-responsive elements (AREs) of transmembrane serine proteases type II (TMPRSS2) gene as one of the major players of male dominancy in severe COVID-19 infection has been under appreciated and needs to be clarified.",

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AU - Tolouian, Ramin

AU - Noshad, Hamid

AU - Tolouian, Audrey

AU - Shoja, Mohammadali Mohajel

AU - Ardalan, Mohammadreza

N1 - Publisher Copyright: Copyright © 2020 The Author(s); Published by Nickan Research Institute. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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AB - Male gender is an obvious risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality rate is higher in men than women. Undoubtedly, gender-related behavioral factors, such as higher amounts of smoking, alcohol consumption, and biological differences in immune systems could make males more vulnerable. The role of androgen-responsive elements (AREs) of transmembrane serine proteases type II (TMPRSS2) gene as one of the major players of male dominancy in severe COVID-19 infection has been under appreciated and needs to be clarified.

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The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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