The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator

Maria Luisa Castellani; D. J. Kempuraj; V. Salini; J. Vecchiet; S. Tetè; C. Ciampoli; F. Conti; G. Cerulli; A. Caraffa; P. Antinolfi; T. C. Theoharides; D. De Amicis; A. Perrella; C. Cuccurullo; P. Boscolo; Y. Shaik

The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator

Maria Luisa Castellani
, D. J. Kempuraj
, V. Salini
, J. Vecchiet
, S. Tetè
, C. Ciampoli
, F. Conti
, G. Cerulli
, A. Caraffa
, P. Antinolfi
, T. C. Theoharides
, D. De Amicis
, A. Perrella
, C. Cuccurullo
, P. Boscolo
, Y. Shaik

Research output: Contribution to journal › Editorial › peer-review

Abstract

IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kB) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.

Original language	English
Pages (from-to)	11-14
Number of pages	4
Journal	Journal of biological regulators and homeostatic agents
Volume	23
Issue number	1
State	Published - Jan 2009
Externally published	Yes

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Physiology
Immunology
Oncology
Endocrinology
Physiology (medical)
Cancer Research

Keywords

Cytokines
IL-33
Interleukins
Mast cell

Cite this

Castellani, M. L., Kempuraj, D. J., Salini, V., Vecchiet, J., Tetè, S., Ciampoli, C., Conti, F., Cerulli, G., Caraffa, A., Antinolfi, P., Theoharides, T. C., De Amicis, D., Perrella, A., Cuccurullo, C., Boscolo, P., & Shaik, Y. (2009). The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator. Journal of biological regulators and homeostatic agents, 23(1), 11-14.

Castellani, ML, Kempuraj, DJ, Salini, V, Vecchiet, J, Tetè, S, Ciampoli, C, Conti, F, Cerulli, G, Caraffa, A, Antinolfi, P, Theoharides, TC, De Amicis, D, Perrella, A, Cuccurullo, C, Boscolo, P & Shaik, Y 2009, 'The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator', Journal of biological regulators and homeostatic agents, vol. 23, no. 1, pp. 11-14.

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title = "The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator",

abstract = "IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kB) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.",

keywords = "Cytokines, IL-33, Interleukins, Mast cell",

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T2 - IL-33 the novel IL-1-family member is a potent mast cell activator

AU - Castellani, Maria Luisa

AU - Kempuraj, D. J.

AU - Salini, V.

AU - Vecchiet, J.

AU - Tetè, S.

AU - Ciampoli, C.

AU - Conti, F.

AU - Cerulli, G.

AU - Caraffa, A.

AU - Antinolfi, P.

AU - Theoharides, T. C.

AU - De Amicis, D.

AU - Perrella, A.

AU - Cuccurullo, C.

AU - Boscolo, P.

AU - Shaik, Y.

PY - 2009/1

Y1 - 2009/1

N2 - IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kB) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.

AB - IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kB) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.

KW - Cytokines

KW - IL-33

KW - Interleukins

KW - Mast cell

UR - https://www.scopus.com/pages/publications/64249128283

UR - https://www.scopus.com/pages/publications/64249128283#tab=citedBy

M3 - Editorial

C2 - 19321041

AN - SCOPUS:64249128283

SN - 0393-974X

VL - 23

SP - 11

EP - 14

JO - Journal of biological regulators and homeostatic agents

JF - Journal of biological regulators and homeostatic agents

IS - 1

ER -

The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator

Abstract

ASJC Scopus Subject Areas

Keywords

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