The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells

T. Lawson; P. Gannett

doi:10.1016/0304-3835(89)90045-1

The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells

T. Lawson
, P. Gannett

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

A crude mixture of capsaicinoids (CAPs) from Capsicum frutrescens, capsaicin (C) and dihydrocapsaicin (DC) but not 4-methyl-dihydrocapsaicin (MC), a synthetic homolog of DC, were mutagenic in the V79 assay. Oxidative metabolism of C and DC by microsomes or ferricyanide yielded a dimer of C or DC. Based on the lack of mutagenicity of MC, the mutagenicities of C and DC and the supporting chemical data, a mechanism of action involving an intermediate phenoxy radical is proposed.

Original language	English
Pages (from-to)	109-113
Number of pages	5
Journal	Cancer Letters
Volume	48
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(89)90045-1
State	Published - Nov 30 1989
Externally published	Yes

ASJC Scopus Subject Areas

Oncology
Cancer Research

Keywords

capsaicin
dihydrocapsaicin
mutagenicity
V79 cells

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10.1016/0304-3835(89)90045-1

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AU - Lawson, T.

AU - Gannett, P.

PY - 1989/11/30

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N2 - A crude mixture of capsaicinoids (CAPs) from Capsicum frutrescens, capsaicin (C) and dihydrocapsaicin (DC) but not 4-methyl-dihydrocapsaicin (MC), a synthetic homolog of DC, were mutagenic in the V79 assay. Oxidative metabolism of C and DC by microsomes or ferricyanide yielded a dimer of C or DC. Based on the lack of mutagenicity of MC, the mutagenicities of C and DC and the supporting chemical data, a mechanism of action involving an intermediate phenoxy radical is proposed.

AB - A crude mixture of capsaicinoids (CAPs) from Capsicum frutrescens, capsaicin (C) and dihydrocapsaicin (DC) but not 4-methyl-dihydrocapsaicin (MC), a synthetic homolog of DC, were mutagenic in the V79 assay. Oxidative metabolism of C and DC by microsomes or ferricyanide yielded a dimer of C or DC. Based on the lack of mutagenicity of MC, the mutagenicities of C and DC and the supporting chemical data, a mechanism of action involving an intermediate phenoxy radical is proposed.

KW - capsaicin

KW - dihydrocapsaicin

KW - mutagenicity

KW - V79 cells

UR - https://www.scopus.com/pages/publications/0024472104

UR - https://www.scopus.com/pages/publications/0024472104#tab=citedBy

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SN - 0304-3835

VL - 48

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EP - 113

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells

Abstract

ASJC Scopus Subject Areas

Keywords

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