The role of calcium in the induction of ornithine decarboxylase in rat HTC cells

Zoe Nakos Canellakis; Theoharis C. Theoharides; Philip K. Bondy; Efthalia T. Triarhos

doi:10.1016/0024-3205(81)90023-0

The role of calcium in the induction of ornithine decarboxylase in rat HTC cells

Zoe Nakos Canellakis
, Theoharis C. Theoharides
, Philip K. Bondy
, Efthalia T. Triarhos

Research output: Contribution to journal › Article › peer-review

Abstract

The possible role of calcium ions in the induction of ornithine decarboxylase (ODC) in rat hepatoma cells in culture (HTC) has been investigated by manipulating cellular calcium levels as follows: a) use of the calcium chelating agent EGTA to inhibit induction of ODC by dibutyryl cyclic AMP (cAMP), b) addition of Ca⁺⁺ to reverse the inhibition of cAMP induction of ODC by EGTA, c) use of a calcium ionophore in the presence of Ca⁺⁺ to induce ODC. In each case there was positive evidence for the participation of Ca⁺⁺ in the induction of ODC.

Original language	English
Pages (from-to)	707-710
Number of pages	4
Journal	Life Sciences
Volume	29
Issue number	7
DOIs	https://doi.org/10.1016/0024-3205(81)90023-0
State	Published - Aug 17 1981
Externally published	Yes

ASJC Scopus Subject Areas

General Biochemistry,Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

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10.1016/0024-3205(81)90023-0

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title = "The role of calcium in the induction of ornithine decarboxylase in rat HTC cells",

abstract = "The possible role of calcium ions in the induction of ornithine decarboxylase (ODC) in rat hepatoma cells in culture (HTC) has been investigated by manipulating cellular calcium levels as follows: a) use of the calcium chelating agent EGTA to inhibit induction of ODC by dibutyryl cyclic AMP (cAMP), b) addition of Ca++ to reverse the inhibition of cAMP induction of ODC by EGTA, c) use of a calcium ionophore in the presence of Ca++ to induce ODC. In each case there was positive evidence for the participation of Ca++ in the induction of ODC.",

author = "Canellakis, \{Zoe Nakos\} and Theoharides, \{Theoharis C.\} and Bondy, \{Philip K.\} and Triarhos, \{Efthalia T.\}",

year = "1981",

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doi = "10.1016/0024-3205(81)90023-0",

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AU - Canellakis, Zoe Nakos

AU - Theoharides, Theoharis C.

AU - Bondy, Philip K.

AU - Triarhos, Efthalia T.

PY - 1981/8/17

Y1 - 1981/8/17

N2 - The possible role of calcium ions in the induction of ornithine decarboxylase (ODC) in rat hepatoma cells in culture (HTC) has been investigated by manipulating cellular calcium levels as follows: a) use of the calcium chelating agent EGTA to inhibit induction of ODC by dibutyryl cyclic AMP (cAMP), b) addition of Ca++ to reverse the inhibition of cAMP induction of ODC by EGTA, c) use of a calcium ionophore in the presence of Ca++ to induce ODC. In each case there was positive evidence for the participation of Ca++ in the induction of ODC.

AB - The possible role of calcium ions in the induction of ornithine decarboxylase (ODC) in rat hepatoma cells in culture (HTC) has been investigated by manipulating cellular calcium levels as follows: a) use of the calcium chelating agent EGTA to inhibit induction of ODC by dibutyryl cyclic AMP (cAMP), b) addition of Ca++ to reverse the inhibition of cAMP induction of ODC by EGTA, c) use of a calcium ionophore in the presence of Ca++ to induce ODC. In each case there was positive evidence for the participation of Ca++ in the induction of ODC.

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UR - https://www.scopus.com/pages/publications/0019823989#tab=citedBy

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AN - SCOPUS:0019823989

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VL - 29

SP - 707

EP - 710

JO - Life Sciences

JF - Life Sciences

IS - 7

ER -

The role of calcium in the induction of ornithine decarboxylase in rat HTC cells

Abstract

ASJC Scopus Subject Areas

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