The streptokinase domain responsible for plasminogen binding

P. Rodríguez; D. Fuentes; E. Muñoz; D. Rivero; D. Orta; S. Alburquerque; S. Perez; V. Besada; L. Herrera

doi:10.1016/0268-9499(94)90016-7

The streptokinase domain responsible for plasminogen binding

P. Rodríguez
, D. Fuentes
, E. Muñoz
, D. Rivero
, D. Orta
, S. Alburquerque
, S. Perez
, V. Besada
, L. Herrera

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The limited proteolysis of soluble recombinant streptokinase by Sepharose-immobilized human plasmin(ogen) complexed with recombinant streptokinase is described. A 17 kDa streptokinase fragment comprising residues Val143 (Glu148) to Arg289 (Lys293) has been shown to be the smallest stable plasminogen binding domain. Moreover, this region seems also to be important for plasminogen activation.

Original language	English
Pages (from-to)	276-285
Number of pages	10
Journal	Fibrinolysis and Proteolysis
Volume	8
Issue number	5
DOIs	https://doi.org/10.1016/0268-9499(94)90016-7
State	Published - Sep 1994
Externally published	Yes

ASJC Scopus Subject Areas

Hematology

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10.1016/0268-9499(94)90016-7

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title = "The streptokinase domain responsible for plasminogen binding",

abstract = "The limited proteolysis of soluble recombinant streptokinase by Sepharose-immobilized human plasmin(ogen) complexed with recombinant streptokinase is described. A 17 kDa streptokinase fragment comprising residues Val143 (Glu148) to Arg289 (Lys293) has been shown to be the smallest stable plasminogen binding domain. Moreover, this region seems also to be important for plasminogen activation.",

author = "P. Rodr{\'i}guez and D. Fuentes and E. Mu{\~n}oz and D. Rivero and D. Orta and S. Alburquerque and S. Perez and V. Besada and L. Herrera",

year = "1994",

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T1 - The streptokinase domain responsible for plasminogen binding

AU - Rodríguez, P.

AU - Fuentes, D.

AU - Muñoz, E.

AU - Rivero, D.

AU - Orta, D.

AU - Alburquerque, S.

AU - Perez, S.

AU - Besada, V.

AU - Herrera, L.

PY - 1994/9

Y1 - 1994/9

N2 - The limited proteolysis of soluble recombinant streptokinase by Sepharose-immobilized human plasmin(ogen) complexed with recombinant streptokinase is described. A 17 kDa streptokinase fragment comprising residues Val143 (Glu148) to Arg289 (Lys293) has been shown to be the smallest stable plasminogen binding domain. Moreover, this region seems also to be important for plasminogen activation.

AB - The limited proteolysis of soluble recombinant streptokinase by Sepharose-immobilized human plasmin(ogen) complexed with recombinant streptokinase is described. A 17 kDa streptokinase fragment comprising residues Val143 (Glu148) to Arg289 (Lys293) has been shown to be the smallest stable plasminogen binding domain. Moreover, this region seems also to be important for plasminogen activation.

UR - https://www.scopus.com/pages/publications/0027937020

UR - https://www.scopus.com/pages/publications/0027937020#tab=citedBy

U2 - 10.1016/0268-9499(94)90016-7

DO - 10.1016/0268-9499(94)90016-7

M3 - Article

AN - SCOPUS:0027937020

SN - 0268-9499

VL - 8

SP - 276

EP - 285

JO - Fibrinolysis and Proteolysis

JF - Fibrinolysis and Proteolysis

IS - 5

ER -

The streptokinase domain responsible for plasminogen binding

Abstract

ASJC Scopus Subject Areas

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