Theoretical modeling of oral absorption of barbiturates

Taravat Ghafourian; Mohammad Barzegar-Jalali

doi:10.1016/S0014-827X(02)01249-1

Theoretical modeling of oral absorption of barbiturates

Taravat Ghafourian
, Mohammad Barzegar-Jalali

Research output: Contribution to journal › Article › peer-review

Abstract

The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption.

Original language	English
Pages (from-to)	565-567
Number of pages	3
Journal	Farmaco
Volume	57
Issue number	7
DOIs	https://doi.org/10.1016/S0014-827X(02)01249-1
State	Published - Jul 4 2002
Externally published	Yes

ASJC Scopus Subject Areas

Pharmaceutical Science
Drug Discovery

Keywords

Absorption
Barbiturate
Gastric
Oral absorption
QSAR

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10.1016/S0014-827X(02)01249-1

Cite this

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title = "Theoretical modeling of oral absorption of barbiturates",

abstract = "The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption. ",

keywords = "Absorption, Barbiturate, Gastric, Oral absorption, QSAR",

author = "Taravat Ghafourian and Mohammad Barzegar-Jalali",

year = "2002",

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AU - Ghafourian, Taravat

AU - Barzegar-Jalali, Mohammad

PY - 2002/7/4

Y1 - 2002/7/4

N2 - The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption.

AB - The structural characteristics governing gastric absorption of barbiturates were studied using QSAR methodology. The results showed that the gastric absorption rate constant could be modeled using the theoretical parameters, accessible surface area, atomic charges and electrostatic potentials. Using molecular connectivity indexes was also satisfactory in modeling the absorption.

KW - Absorption

KW - Barbiturate

KW - Gastric

KW - Oral absorption

KW - QSAR

UR - https://www.scopus.com/pages/publications/0037019129

UR - https://www.scopus.com/pages/publications/0037019129#tab=citedBy

U2 - 10.1016/S0014-827X(02)01249-1

DO - 10.1016/S0014-827X(02)01249-1

M3 - Article

C2 - 12164215

AN - SCOPUS:0037019129

SN - 0014-827X

VL - 57

SP - 565

EP - 567

JO - Farmaco

JF - Farmaco

IS - 7

ER -

Theoretical modeling of oral absorption of barbiturates

Abstract

ASJC Scopus Subject Areas

Keywords

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