Abstract
Standard options for reducing seizure activity include pharmacological intervention, vagal nerve stimulation, and/or surgical resection. However, at least 30% of epileptic patients have uncontrolled seizures despite antiepileptic medications, and not all drug-resistant patients are candidates for surgery. Electrical stimulation in the central nervous system, as a potential therapy, is now under investigation. Initial results are promising, but many important questions remain unanswered. Currently, a number of targets are being investigated, as are a variety of stimulation protocols, both in animal models and in human clinical trials. The present chapter presents an introduction to the research in this field.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of Basic Epilepsy Research |
| Publisher | Elsevier |
| Pages | 1426-1430 |
| Number of pages | 5 |
| ISBN (Electronic) | 9780123739612 |
| ISBN (Print) | 9780123739612 |
| DOIs | |
| State | Published - Jan 1 2009 |
| Externally published | Yes |
Publication series
| Name | Encyclopedia of Basic Epilepsy Research |
|---|
Bibliographical note
Publisher Copyright:© 2009 Elsevier Ltd. All rights reserved.
ASJC Scopus Subject Areas
- General Medicine
- General Neuroscience
Keywords
- Animal model
- CNS
- Convulsion
- DBS
- Electrical stimulation
- Epilepsy
- Epileptiform
- Human
- Kindling
- Nerve
- Neuromodulation
- PNS
- Seizure
- Therapy