Triciribine

Vladimir Beljanski

doi:10.1016/B978-008055232-3.64483-6

Triciribine

Vladimir Beljanski

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Triciribine is a synthetic, cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1,-2, and-3, which may result in the inhibition of Akt-overexpressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and .... . © 2009

Original language	English
Title of host publication	xPharm
Subtitle of host publication	The Comprehensive Pharmacology Reference
Editors	S.J. Enna, David B. Bylund
Publisher	Elsevier Inc.
Pages	1-5
Number of pages	5
ISBN (Print)	9780080552323
DOIs	https://doi.org/10.1016/B978-008055232-3.64483-6
State	Published - 2009
Externally published	Yes

ASJC Scopus Subject Areas

General Pharmacology, Toxicology and Pharmaceutics

Disciplines

Medicine and Health Sciences

Access to Document

10.1016/B978-008055232-3.64483-6

Cite this

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title = "Triciribine",

abstract = "Triciribine is a synthetic, cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1,-2, and-3, which may result in the inhibition of Akt-overexpressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and .... . {\textcopyright} 2009",

author = "Vladimir Beljanski",

year = "2009",

doi = "10.1016/B978-008055232-3.64483-6",

language = "English",

isbn = "9780080552323",

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editor = "S.J. Enna and Bylund, \{David B.\}",

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T1 - Triciribine

AU - Beljanski, Vladimir

PY - 2009

Y1 - 2009

N2 - Triciribine is a synthetic, cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1,-2, and-3, which may result in the inhibition of Akt-overexpressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and .... . © 2009

AB - Triciribine is a synthetic, cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1,-2, and-3, which may result in the inhibition of Akt-overexpressing tumor cell proliferation. Akts are anti-apoptotic serine/threonine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and .... . © 2009

UR - https://www.scopus.com/pages/publications/84884023719

UR - https://www.scopus.com/pages/publications/84884023719#tab=citedBy

U2 - 10.1016/B978-008055232-3.64483-6

DO - 10.1016/B978-008055232-3.64483-6

M3 - Chapter

AN - SCOPUS:84884023719

SN - 9780080552323

SP - 1

EP - 5

BT - xPharm

A2 - Enna, S.J.

A2 - Bylund, David B.

PB - Elsevier Inc.

ER -

Triciribine

Abstract

ASJC Scopus Subject Areas

Disciplines

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