Vascular calcification: An important understanding in nephrology

Sepideh Zununi Vahed; Soroush Mostafavi; Seyed Mahdi Hosseiniyan Khatibi; Mohammadali M. Shoja; Mohammadreza Ardalan

doi:10.2147/VHRM.S242685

Vascular calcification: An important understanding in nephrology

Sepideh Zununi Vahed
, Soroush Mostafavi
, Seyed Mahdi Hosseiniyan Khatibi
, Mohammadali M. Shoja
, Mohammadreza Ardalan

Research output: Contribution to journal › Review article › peer-review

Abstract

Vascular calcification (VC) is a life-threatening state in chronic kidney disease (CKD). High cardiovascular mortality and morbidity of CKD cases may root from medial VC promoted by hyperphosphatemia. Vascular calcification is an active, highly regulated, and complex biological process that is mediated by genetics, epigenetics, dysregulated form of matrix mineral metabolism, hormones, and the activation of cellular signaling pathways. Moreover, gut microbiome as a source of uremic toxins (eg, phosphate, advanced glycation end products and indoxyl-sulfate) can be regarded as a potential contributor to VC in CKD. Here, an update on different cellular and molecular processes involved in VC in CKD is discussed to elucidate the probable therapeutic pathways in the future.

Original language	English
Pages (from-to)	167-180
Number of pages	14
Journal	Vascular Health and Risk Management
Volume	16
DOIs	https://doi.org/10.2147/VHRM.S242685
State	Published - 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Zununi Vahed et al.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Hematology
Public Health, Environmental and Occupational Health
Cardiology and Cardiovascular Medicine
Pharmacology (medical)

Keywords

Calcification
Chronic kidney disease
CKD
Hyperphosphatemia
Uremia
Uremic toxins

Access to Document

10.2147/VHRM.S242685

Cite this

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title = "Vascular calcification: An important understanding in nephrology",

abstract = "Vascular calcification (VC) is a life-threatening state in chronic kidney disease (CKD). High cardiovascular mortality and morbidity of CKD cases may root from medial VC promoted by hyperphosphatemia. Vascular calcification is an active, highly regulated, and complex biological process that is mediated by genetics, epigenetics, dysregulated form of matrix mineral metabolism, hormones, and the activation of cellular signaling pathways. Moreover, gut microbiome as a source of uremic toxins (eg, phosphate, advanced glycation end products and indoxyl-sulfate) can be regarded as a potential contributor to VC in CKD. Here, an update on different cellular and molecular processes involved in VC in CKD is discussed to elucidate the probable therapeutic pathways in the future.",

keywords = "Calcification, Chronic kidney disease, CKD, Hyperphosphatemia, Uremia, Uremic toxins",

author = "Vahed, \{Sepideh Zununi\} and Soroush Mostafavi and Khatibi, \{Seyed Mahdi Hosseiniyan\} and Shoja, \{Mohammadali M.\} and Mohammadreza Ardalan",

note = "Publisher Copyright: {\textcopyright} 2020 Zununi Vahed et al.",

year = "2020",

doi = "10.2147/VHRM.S242685",

language = "English",

volume = "16",

pages = "167--180",

journal = "Vascular Health and Risk Management",

issn = "1176-6344",

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}

TY - JOUR

T1 - Vascular calcification

T2 - An important understanding in nephrology

AU - Vahed, Sepideh Zununi

AU - Mostafavi, Soroush

AU - Khatibi, Seyed Mahdi Hosseiniyan

AU - Shoja, Mohammadali M.

AU - Ardalan, Mohammadreza

PY - 2020

Y1 - 2020

N2 - Vascular calcification (VC) is a life-threatening state in chronic kidney disease (CKD). High cardiovascular mortality and morbidity of CKD cases may root from medial VC promoted by hyperphosphatemia. Vascular calcification is an active, highly regulated, and complex biological process that is mediated by genetics, epigenetics, dysregulated form of matrix mineral metabolism, hormones, and the activation of cellular signaling pathways. Moreover, gut microbiome as a source of uremic toxins (eg, phosphate, advanced glycation end products and indoxyl-sulfate) can be regarded as a potential contributor to VC in CKD. Here, an update on different cellular and molecular processes involved in VC in CKD is discussed to elucidate the probable therapeutic pathways in the future.

AB - Vascular calcification (VC) is a life-threatening state in chronic kidney disease (CKD). High cardiovascular mortality and morbidity of CKD cases may root from medial VC promoted by hyperphosphatemia. Vascular calcification is an active, highly regulated, and complex biological process that is mediated by genetics, epigenetics, dysregulated form of matrix mineral metabolism, hormones, and the activation of cellular signaling pathways. Moreover, gut microbiome as a source of uremic toxins (eg, phosphate, advanced glycation end products and indoxyl-sulfate) can be regarded as a potential contributor to VC in CKD. Here, an update on different cellular and molecular processes involved in VC in CKD is discussed to elucidate the probable therapeutic pathways in the future.

KW - Calcification

KW - Chronic kidney disease

KW - CKD

KW - Hyperphosphatemia

KW - Uremia

KW - Uremic toxins

UR - https://www.scopus.com/pages/publications/85085125340

UR - https://www.scopus.com/pages/publications/85085125340#tab=citedBy

U2 - 10.2147/VHRM.S242685

DO - 10.2147/VHRM.S242685

M3 - Review article

C2 - 32494148

AN - SCOPUS:85085125340

SN - 1176-6344

VL - 16

SP - 167

EP - 180

JO - Vascular Health and Risk Management

JF - Vascular Health and Risk Management

ER -

Vascular calcification: An important understanding in nephrology

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

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