Water-Mediated Correlations in DNA-Enzyme Interactions

Philip Kurian; Antonio Capolupo; Travis J. Craddock; Giuseppe Vitiello

doi:10.1016/j.physleta.2017.10.038

Water-Mediated Correlations in DNA-Enzyme Interactions

Philip Kurian
, Antonio Capolupo
, Travis J. Craddock
, Giuseppe Vitiello

College of Psychology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

<p> In this letter we consider dipole-mediated correlations between DNA and enzymes in the context of their water environment. Such correlations emerge from electric dipole-dipole interactions between aromatic ring structures in DNA and in enzymes. We show that there are matching collective modes between DNA and enzyme dipole fields, and that a dynamic time-averaged polarization vanishes in the water dipole field only if either DNA, enzyme, or both are absent from the sample. This persistent field may serve as the <a href="https://www.sciencedirect.com/topics/physics-and-astronomy/electromagnetism" target="_blank" title="Learn more about Electromagnetism"> electromagnetic </a> image that, in popular colloquialisms about DNA <a href="https://www.sciencedirect.com/topics/physics-and-astronomy/biochemistry" target="_blank" title="Learn more about Biochemistry"> biochemistry </a> , allows enzymes to “scan” or “read” the double helix. Topologically nontrivial configurations in the coherent ground state requiring clamplike enzyme behavior on the DNA may stem, ultimately, from spontaneously broken gauge symmetries.</p>

Original language	American English
Journal	Physics Letters A
Volume	382
DOIs	https://doi.org/10.1016/j.physleta.2017.10.038
State	Published - Jan 1 2018

Keywords

EcoRI restriction endonuclease
aromatic networks
dipole oscillations
quantum biologyTaq DNA polymerase
water dipole field

Disciplines

Psychology

Access to Document

10.1016/j.physleta.2017.10.038License: Unspecified

https://www.sciencedirect.com/science/article/pii/S0375960117310356#!

Cite this

@article{9c7ea24a8d71403485c383a23e65c1af,

title = "Water-Mediated Correlations in DNA-Enzyme Interactions",

abstract = " In this letter we consider dipole-mediated correlations between DNA and enzymes in the context of their water environment. Such correlations emerge from electric dipole-dipole interactions between aromatic ring structures in DNA and in enzymes. We show that there are matching collective modes between DNA and enzyme dipole fields, and that a dynamic time-averaged polarization vanishes in the water dipole field only if either DNA, enzyme, or both are absent from the sample. This persistent field may serve as the electromagnetic image that, in popular colloquialisms about DNA biochemistry , allows enzymes to \“scan\” or \“read\” the double helix. Topologically nontrivial configurations in the coherent ground state requiring clamplike enzyme behavior on the DNA may stem, ultimately, from spontaneously broken gauge symmetries.",

keywords = "EcoRI restriction endonuclease, aromatic networks, dipole oscillations, quantum biologyTaq DNA polymerase, water dipole field",

author = "Philip Kurian and Antonio Capolupo and Craddock, \{Travis J.\} and Giuseppe Vitiello",

year = "2018",

month = jan,

day = "1",

doi = "10.1016/j.physleta.2017.10.038",

language = "American English",

volume = "382",

journal = "Physics Letters A",

issn = "0375-9601",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Water-Mediated Correlations in DNA-Enzyme Interactions

AU - Kurian, Philip

AU - Capolupo, Antonio

AU - Craddock, Travis J.

AU - Vitiello, Giuseppe

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In this letter we consider dipole-mediated correlations between DNA and enzymes in the context of their water environment. Such correlations emerge from electric dipole-dipole interactions between aromatic ring structures in DNA and in enzymes. We show that there are matching collective modes between DNA and enzyme dipole fields, and that a dynamic time-averaged polarization vanishes in the water dipole field only if either DNA, enzyme, or both are absent from the sample. This persistent field may serve as the electromagnetic image that, in popular colloquialisms about DNA biochemistry , allows enzymes to “scan” or “read” the double helix. Topologically nontrivial configurations in the coherent ground state requiring clamplike enzyme behavior on the DNA may stem, ultimately, from spontaneously broken gauge symmetries.

AB - In this letter we consider dipole-mediated correlations between DNA and enzymes in the context of their water environment. Such correlations emerge from electric dipole-dipole interactions between aromatic ring structures in DNA and in enzymes. We show that there are matching collective modes between DNA and enzyme dipole fields, and that a dynamic time-averaged polarization vanishes in the water dipole field only if either DNA, enzyme, or both are absent from the sample. This persistent field may serve as the electromagnetic image that, in popular colloquialisms about DNA biochemistry , allows enzymes to “scan” or “read” the double helix. Topologically nontrivial configurations in the coherent ground state requiring clamplike enzyme behavior on the DNA may stem, ultimately, from spontaneously broken gauge symmetries.

KW - EcoRI restriction endonuclease

KW - aromatic networks

KW - dipole oscillations

KW - quantum biologyTaq DNA polymerase

KW - water dipole field

UR - https://nsuworks.nova.edu/cps_facarticles/1634

UR - https://www.sciencedirect.com/science/article/pii/S0375960117310356#!

U2 - 10.1016/j.physleta.2017.10.038

DO - 10.1016/j.physleta.2017.10.038

M3 - Article

SN - 0375-9601

VL - 382

JO - Physics Letters A

JF - Physics Letters A

ER -

Water-Mediated Correlations in DNA-Enzyme Interactions

Abstract

Keywords

Disciplines

Access to Document

Other files and links

Fingerprint

Cite this