Objective. This study aims to compare several mechanical and optical properties between three different CAD/CAM materials. The properties tested are: flexural strength, modulus of elasticity, hardness, translucency and surface gloss. Background. Typically, CAD/CAM restorations are either ceramic based or resin based. A new resin-ceramic hybrid material has recently been introduced and is thought to combine the advantages of both materials. Methods. Samples were divided into three groups, leucite-reinforced porcelain (IPS Empress CAD), lithium dicilicate (IPS e.max CAD) and resin-ceramic hybrid material (Vita Enamic). Twenty-six bar-shaped specimens were fabricated for each group by cutting standard CAD/CAM blocks. 3-point bending test and Vickers diamond pyramid indenters were used to test the flexural strength and microhardness respectively. Seven veneers were fabricated for each material with a thickness of 0.5 mm using a CAD/CAM milling machine. These veneers were used to test the optical properties via spectrophotometry and gloss-meter analysis. One-way ANOVA, and the Tukey HSD post hoc test were used for statistical analysis between the groups (P