Objective: High translucency zirconia has been developed for esthetically demanding dental cases with the objective of improving light transmittance. The purpose of this in vitro study is to compare the translucency and flexural strength of high translucency zirconia with conventional zirconia and lithium disilicate ceramics, all of which are options for indirect dental restorative applications. Methods: Three dental ceramic materials were selected: Group 1: conventional zirconia; group 2: high translucent zirconia; and group 3: lithium disilicate glass-ceramic. Fifteen disk-shaped specimens (10mm in diameter) of each material were fabricated at 0.5mm, 0.75mm, and 1 mm thicknesses as subgroups A, B, and C respectively (n=135). The morphologies of the specimens were observed by a scanning electron microscopy at 5000X magnifications. Translucency and flexural strength of all specimens were measured using spectrophotometry and biaxial flexural testing respectively. The data was analyzed by ANOVA followed by post-hoc test (p