Idea Analysis for the Development of Clinical Trial Strategies

  • Roberta S. Horowitz

    Student thesis: Doctoral ThesisDoctor of Philosophy

    Abstract

    Idea Analysis was investigated to determine its ability to organize scientific information and explain the results of specialists' deliberations in designing new clinical trials. Ideas have long been recognized as the engine of creativity. By focusing on the capture of ideas from the scientific literature, idea analysis procedures enable the arrangement of the information into forms consistent with those developed by subject specialists. The most obvious example is the concept structure. Ideas containing a common frequently occurring term/phrase can be depicted as a primary node in the concept network. Related terms will appear as elements associated with that node. Ideas containing couplets of primary nodal terms/phrases can be used to link nodes, thus, completing the paths in the network. Using this methodology, information specialists can build and maintain knowledge structures for use by students, subject specialists and interested others. In contrast with expert systems, idea analysis does not attempt to duplicate thought processes performed by experts in a subject. Instead, it focuses on the management of ideas and the arrangement of those ideas using organizational models. The application of these techniques to the scientific literature dealing with brain tumors and to clinical trial protocols developed by subject specialists is illustrative. This study showed that, in the brain tumor literature and clinical trial protocols, the idea analysis approach was effective in accomplishing the two tasks required: 1. Organization of complex material into succinct and understandable descriptions--tabular and graphic; 2. provision of explanations of expert-derived research strategies and/or plans. This methodology enhanced identification, extraction, computerization and incorporation of ideas into knowledge structures in an efficient and effective manner.
    Date of AwardJan 1 1995
    Original languageEnglish
    SupervisorMarlyn Kemper Littman (Supervisor), John M. Weiner (Advisor) & Junping Sun (Advisor)

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