The sera of 65 patients with primary lung cancer and matched controls were tested for Herpes simplex type-1 (HSV-1) and type-2 (HSV-2) complement fixing, and neutralizing antibody. The frequency of HSV-1 neutralizing antibody was significantly higher (P In order to determine whether tobacco tars combined with human herpesvirus were capable of inducing neoplastic changes in embryonic cell in vitro, numerous attempts were made to oncogenically transform germfree rat embryo fibroblasts by exposing them to several combinations of ultraviolet inactivated HSV-1 and tobacco tar condensates. In a two-year period several morphologically transformed cell cultures were obtained following such treatments, but they were not oncogenic in rats. These studies were completed prior to the observation of others that many rodent cells in culture are resistant to oncogenic transformation by potent carcinogens.
| Date of Award | Jan 1 1975 |
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| Original language | English |
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| Supervisor | Joel Warren (Supervisor), Vincent R. Saurino (Advisor), Raymond P. Porter (Advisor) & Robert A. Menzies (Advisor) |
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